Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia
Previous studies have shown that, the clinical features and prognosis of ZNF384-rearranged pediatric acute lymphoblastic leukemia (ALL) depend on its translocation partners. We report two cases of TCF4-ZNF384 fusion, one 6-year-old girl and one 10-year-old boy, both diagnosed by whole-transcriptome...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.900054/full |
| _version_ | 1798040090057900032 |
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| author | Zhengyu Wu Fang Zhang Chengzhu Liu Shuhong Shen Shuhong Shen Jinhua Chu Linhai Yang Zhiwei Xie Yu Liu Kangkang Liu Ningling Wang |
| author_facet | Zhengyu Wu Fang Zhang Chengzhu Liu Shuhong Shen Shuhong Shen Jinhua Chu Linhai Yang Zhiwei Xie Yu Liu Kangkang Liu Ningling Wang |
| author_sort | Zhengyu Wu |
| collection | DOAJ |
| description | Previous studies have shown that, the clinical features and prognosis of ZNF384-rearranged pediatric acute lymphoblastic leukemia (ALL) depend on its translocation partners. We report two cases of TCF4-ZNF384 fusion, one 6-year-old girl and one 10-year-old boy, both diagnosed by whole-transcriptome sequencing, and TCF4 is the newest fusion partner of ZNF384. As illustrated in this first report of TCF4-ZNF384 fusion in ALL patients, the identification of patients with ZNF384 rearrangement in ALL patients is critical to elucidate outcomes associated with a specific rearrangement and to develop appropriate treatment strategies. In addition, the development of other methods to detect ZNF384 specific translocation partners and leukemia specific targeting agents is of great significance to further improve the prognosis of ALL with ZNF384-rearrangement. |
| first_indexed | 2024-04-11T22:02:42Z |
| format | Article |
| id | doaj.art-e38ced66d0f74fb898ca44236fb0c1f7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T22:02:42Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e38ced66d0f74fb898ca44236fb0c1f72022-12-22T04:00:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.900054900054Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemiaZhengyu Wu0Fang Zhang1Chengzhu Liu2Shuhong Shen3Shuhong Shen4Jinhua Chu5Linhai Yang6Zhiwei Xie7Yu Liu8Kangkang Liu9Ningling Wang10Pediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPediatric Translational Medicine Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPediatric Translational Medicine Institute, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaKey Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaKey Laboratory of Pediatric Hematology & Oncology Ministry of Health, Department of Hematology & Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPediatrics, the Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaPrevious studies have shown that, the clinical features and prognosis of ZNF384-rearranged pediatric acute lymphoblastic leukemia (ALL) depend on its translocation partners. We report two cases of TCF4-ZNF384 fusion, one 6-year-old girl and one 10-year-old boy, both diagnosed by whole-transcriptome sequencing, and TCF4 is the newest fusion partner of ZNF384. As illustrated in this first report of TCF4-ZNF384 fusion in ALL patients, the identification of patients with ZNF384 rearrangement in ALL patients is critical to elucidate outcomes associated with a specific rearrangement and to develop appropriate treatment strategies. In addition, the development of other methods to detect ZNF384 specific translocation partners and leukemia specific targeting agents is of great significance to further improve the prognosis of ALL with ZNF384-rearrangement.https://www.frontiersin.org/articles/10.3389/fonc.2022.900054/fullacute lymphoblastic leukemiaZNF384RNA sequencingTCF4pediatic |
| spellingShingle | Zhengyu Wu Fang Zhang Chengzhu Liu Shuhong Shen Shuhong Shen Jinhua Chu Linhai Yang Zhiwei Xie Yu Liu Kangkang Liu Ningling Wang Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia Frontiers in Oncology acute lymphoblastic leukemia ZNF384 RNA sequencing TCF4 pediatic |
| title | Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia |
| title_full | Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia |
| title_fullStr | Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia |
| title_full_unstemmed | Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia |
| title_short | Whole transcriptome sequencing reveals a TCF4-ZNF384 fusion in acute lymphoblastic leukemia |
| title_sort | whole transcriptome sequencing reveals a tcf4 znf384 fusion in acute lymphoblastic leukemia |
| topic | acute lymphoblastic leukemia ZNF384 RNA sequencing TCF4 pediatic |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.900054/full |
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