Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study
<b>Background:</b> Predicting stroke risk in patients with carotid artery stenosis (CS) remains challenging. Circulating biomarkers seem to provide improvements with respect to risk stratification. <b>Methods:</b> Study patients who underwent carotid endarterectomy were categ...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/2/506 |
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| author | Norbert Svoboda Karolina Kočí Anna Seidlová Václav Mandys Jiří Suttnar Alžběta Hlaváčková Ondřej Kučerka David Netuka Martin Malý |
| author_facet | Norbert Svoboda Karolina Kočí Anna Seidlová Václav Mandys Jiří Suttnar Alžběta Hlaváčková Ondřej Kučerka David Netuka Martin Malý |
| author_sort | Norbert Svoboda |
| collection | DOAJ |
| description | <b>Background:</b> Predicting stroke risk in patients with carotid artery stenosis (CS) remains challenging. Circulating biomarkers seem to provide improvements with respect to risk stratification. <b>Methods:</b> Study patients who underwent carotid endarterectomy were categorized into four groups according to symptomatology and compared as follows: symptomatic with asymptomatic patients; and asymptomatic patients including amaurosis fugax (AF) (asymptomatic + AF group) with patients with a transient ischemic attack (TIA) or brain stroke (BS) (hemispheric brain stroke group). Carotid specimens were histologically analyzed and classified based on the American Heart Classification (AHA) standard. As a marker of OS, the plasma levels of malondialdehyde (MDA) were measured. Comparisons of MDA plasma levels between groups were analyzed. <b>Results</b>: In total, 35 patients were included in the study. There were 22 (63%) patients in the asymptomatic group and 13 (37%) in the symptomatic group. Atheromatous plaque (<i>p =</i> 0.03) and old hemorrhage (<i>p =</i> 0.05), fibrous plaque (<i>p =</i> 0.04), myxoid changes (<i>p =</i> 0.02), plaques without hemorrhage (<i>p =</i> 0.04), significant neovascularization (<i>p =</i> 0.04) and AHA classification (<i>p =</i> 0.006) had significant correlations with clinical presentation. There were 26 (74%) patients in the asymptomatic group and 9 (26%) in the hemispheric brain stroke group. Atheromatous plaque (<i>p =</i> 0.02), old hemorrhage (<i>p =</i> 0.05) and plaques without neovascularization (<i>p =</i> 0.02), fibrous plaque (<i>p =</i> 0.03), plaques without hemorrhage (<i>p =</i> 0.02) and AHA classification (<i>p =</i> 0.01) had significant correlations with clinical presentation. There was no significant difference between symptomatic and asymptomatic groups with respect to MDA plasma levels (<i>p</i> = 0.232). A significant difference was observed when MDA plasma levels were compared to asymptomatic + AF and the hemispheric stroke group (<i>p</i> = 0.002). <b>Conclusions</b>: MDA plasma level correlates with the risk of hemispheric stroke (TIA or BS) and is a reliable marker of plaque vulnerability in carotid artery stenosis. |
| first_indexed | 2024-03-11T09:14:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T09:14:29Z |
| publishDate | 2023-02-01 |
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| series | Antioxidants |
| spelling | doaj.art-e38dc794082543e68aa196b5a6b45cac2023-11-16T18:49:11ZengMDPI AGAntioxidants2076-39212023-02-0112250610.3390/antiox12020506Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot StudyNorbert Svoboda0Karolina Kočí1Anna Seidlová2Václav Mandys3Jiří Suttnar4Alžběta Hlaváčková5Ondřej Kučerka6David Netuka7Martin Malý8First Faculty of Medicine, Charles University, 169 02 Prague, Czech RepublicUniversity Military Hospital Prague, 168 02 Prague, Czech RepublicFirst Faculty of Medicine, Charles University, 169 02 Prague, Czech RepublicThird Faculty of Medicine, Charles University, 100 00 Prague, Czech RepublicInstitute of Haematology and Blood Transfusion, 120 00 Prague, Czech RepublicInstitute of Haematology and Blood Transfusion, 120 00 Prague, Czech RepublicUniversity Military Hospital Prague, 168 02 Prague, Czech RepublicFirst Faculty of Medicine, Charles University, 169 02 Prague, Czech RepublicFirst Faculty of Medicine, Charles University, 169 02 Prague, Czech Republic<b>Background:</b> Predicting stroke risk in patients with carotid artery stenosis (CS) remains challenging. Circulating biomarkers seem to provide improvements with respect to risk stratification. <b>Methods:</b> Study patients who underwent carotid endarterectomy were categorized into four groups according to symptomatology and compared as follows: symptomatic with asymptomatic patients; and asymptomatic patients including amaurosis fugax (AF) (asymptomatic + AF group) with patients with a transient ischemic attack (TIA) or brain stroke (BS) (hemispheric brain stroke group). Carotid specimens were histologically analyzed and classified based on the American Heart Classification (AHA) standard. As a marker of OS, the plasma levels of malondialdehyde (MDA) were measured. Comparisons of MDA plasma levels between groups were analyzed. <b>Results</b>: In total, 35 patients were included in the study. There were 22 (63%) patients in the asymptomatic group and 13 (37%) in the symptomatic group. Atheromatous plaque (<i>p =</i> 0.03) and old hemorrhage (<i>p =</i> 0.05), fibrous plaque (<i>p =</i> 0.04), myxoid changes (<i>p =</i> 0.02), plaques without hemorrhage (<i>p =</i> 0.04), significant neovascularization (<i>p =</i> 0.04) and AHA classification (<i>p =</i> 0.006) had significant correlations with clinical presentation. There were 26 (74%) patients in the asymptomatic group and 9 (26%) in the hemispheric brain stroke group. Atheromatous plaque (<i>p =</i> 0.02), old hemorrhage (<i>p =</i> 0.05) and plaques without neovascularization (<i>p =</i> 0.02), fibrous plaque (<i>p =</i> 0.03), plaques without hemorrhage (<i>p =</i> 0.02) and AHA classification (<i>p =</i> 0.01) had significant correlations with clinical presentation. There was no significant difference between symptomatic and asymptomatic groups with respect to MDA plasma levels (<i>p</i> = 0.232). A significant difference was observed when MDA plasma levels were compared to asymptomatic + AF and the hemispheric stroke group (<i>p</i> = 0.002). <b>Conclusions</b>: MDA plasma level correlates with the risk of hemispheric stroke (TIA or BS) and is a reliable marker of plaque vulnerability in carotid artery stenosis.https://www.mdpi.com/2076-3921/12/2/506carotid stenosisplaqueatheroscleroticoxidative stressendarterectomycarotid |
| spellingShingle | Norbert Svoboda Karolina Kočí Anna Seidlová Václav Mandys Jiří Suttnar Alžběta Hlaváčková Ondřej Kučerka David Netuka Martin Malý Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study Antioxidants carotid stenosis plaque atherosclerotic oxidative stress endarterectomy carotid |
| title | Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study |
| title_full | Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study |
| title_fullStr | Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study |
| title_full_unstemmed | Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study |
| title_short | Oxidative Stress as a Reliable Biomarker of Carotid Plaque Instability: A Pilot Study |
| title_sort | oxidative stress as a reliable biomarker of carotid plaque instability a pilot study |
| topic | carotid stenosis plaque atherosclerotic oxidative stress endarterectomy carotid |
| url | https://www.mdpi.com/2076-3921/12/2/506 |
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