Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles
There is an increasing demand on synthesizing pharmaceuticals and biomaterials that possess antimicrobial and/or antiviral activities. In this respective silver nanoparticles are known for their excellent antimicrobial activity. Nevertheless, their uncontrolled release in a biological medium can ind...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/6/1481 |
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| author | Inés García Camino Trobajo Zakariae Amghouz Alaa Adawy |
| author_facet | Inés García Camino Trobajo Zakariae Amghouz Alaa Adawy |
| author_sort | Inés García |
| collection | DOAJ |
| description | There is an increasing demand on synthesizing pharmaceuticals and biomaterials that possess antimicrobial and/or antiviral activities. In this respective silver nanoparticles are known for their excellent antimicrobial activity. Nevertheless, their uncontrolled release in a biological medium can induce a cytotoxic effect. For this, we explored the use of nanolayered metal phosphates based on titanium and zirconium as materials that can be enriched with silver nanoparticles. Employing the hydrothermal route, crystalline α-phases of zirconium and titanium phosphates (α-ZrP, α-TiP) were synthesized and there after surface-enriched with silver nanoparticles. The structural assessment confirmed the stability of the structures and their sizes are in the nanoscale at least in one dimension. The cytocompatibility assays confirmed the biocompatibility of the pristine phases and the antimicrobial assay confirmed that both silver-enriched nanolayered structures maintain an antibacterial effect at reasonably low concentrations. |
| first_indexed | 2024-03-10T13:08:12Z |
| format | Article |
| id | doaj.art-e38e3dc20813417cb0ed2a28d12002e8 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T13:08:12Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-e38e3dc20813417cb0ed2a28d12002e82023-11-21T10:57:22ZengMDPI AGMaterials1996-19442021-03-01146148110.3390/ma14061481Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver NanoparticlesInés García0Camino Trobajo1Zakariae Amghouz2Alaa Adawy3Nanomaterials and Nanotechnology Research Centre—CINN (CSIC), 33940 El Entrego, SpainNanomaterials and Nanotechnology Research Centre—CINN (CSIC), 33940 El Entrego, SpainDepartment of Material Science and Metallurgical Engineering, University of Oviedo, 33203 Gijón, SpainLaboratory of High-Resolution Transmission Electron Microscopy, Institute for Scientific and Technological, Resources, University of Oviedo, 33006 Oviedo, SpainThere is an increasing demand on synthesizing pharmaceuticals and biomaterials that possess antimicrobial and/or antiviral activities. In this respective silver nanoparticles are known for their excellent antimicrobial activity. Nevertheless, their uncontrolled release in a biological medium can induce a cytotoxic effect. For this, we explored the use of nanolayered metal phosphates based on titanium and zirconium as materials that can be enriched with silver nanoparticles. Employing the hydrothermal route, crystalline α-phases of zirconium and titanium phosphates (α-ZrP, α-TiP) were synthesized and there after surface-enriched with silver nanoparticles. The structural assessment confirmed the stability of the structures and their sizes are in the nanoscale at least in one dimension. The cytocompatibility assays confirmed the biocompatibility of the pristine phases and the antimicrobial assay confirmed that both silver-enriched nanolayered structures maintain an antibacterial effect at reasonably low concentrations.https://www.mdpi.com/1996-1944/14/6/1481inorganic layered nanomaterialszirconium phosphatetitanium phosphatesilver nanoparticlescytocompatibilityantimicrobial activity |
| spellingShingle | Inés García Camino Trobajo Zakariae Amghouz Alaa Adawy Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles Materials inorganic layered nanomaterials zirconium phosphate titanium phosphate silver nanoparticles cytocompatibility antimicrobial activity |
| title | Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles |
| title_full | Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles |
| title_fullStr | Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles |
| title_full_unstemmed | Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles |
| title_short | Nanolayered Metal Phosphates as Biocompatible Reservoirs for Antimicrobial Silver Nanoparticles |
| title_sort | nanolayered metal phosphates as biocompatible reservoirs for antimicrobial silver nanoparticles |
| topic | inorganic layered nanomaterials zirconium phosphate titanium phosphate silver nanoparticles cytocompatibility antimicrobial activity |
| url | https://www.mdpi.com/1996-1944/14/6/1481 |
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