Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen
In this study, we describe the magnetic and structural properties and cytotoxicity of drug delivery composite (DDC) consisting of hexagonally ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe<sub>2</sub>O<sub>3</sub>), and the drug naproxen (Napro). The nonster...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/11/4/901 |
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| author | Adriana Zeleňáková Jaroslava Szűcsová Ľuboš Nagy Vladimír Girman Vladimír Zeleňák Veronika Huntošová |
| author_facet | Adriana Zeleňáková Jaroslava Szűcsová Ľuboš Nagy Vladimír Girman Vladimír Zeleňák Veronika Huntošová |
| author_sort | Adriana Zeleňáková |
| collection | DOAJ |
| description | In this study, we describe the magnetic and structural properties and cytotoxicity of drug delivery composite (DDC) consisting of hexagonally ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe<sub>2</sub>O<sub>3</sub>), and the drug naproxen (Napro). The nonsteroidal anti-inflammatory drug (NSAID) naproxen was adsorbed into the pores of MCM-41 silica after the ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) encapsulation. Our results confirm the suppression of the Brownian relaxation process caused by a “gripping effect” since the rotation of the whole particle encapsulated in the porous system of mesoporous silica was disabled. This behavior was observed for the first time, to the best of our knowledge. Therefore, the dominant relaxation mechanism in powder and liquid form is the Néel process when the rotation of the nanoparticle’s magnetic moment is responsible for the relaxation. The in vitro cytotoxicity tests were performed using human glioma U87 MG cells, and the moderate manifestation of cell death, although at high concentrations of studied systems, was observed with fluorescent labeling by AnnexinV/FITC. All our results indicate that the as-prepared MCM-41/Napro/Fe<sub>2</sub>O<sub>3</sub> composite has a potential application as a drug nanocarrier for magnetic-targeted drug delivery. |
| first_indexed | 2024-03-10T12:43:01Z |
| format | Article |
| id | doaj.art-e38f3400ec574151bb03e4ea2b9a1fc6 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T12:43:01Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-e38f3400ec574151bb03e4ea2b9a1fc62023-11-21T13:45:56ZengMDPI AGNanomaterials2079-49912021-04-0111490110.3390/nano11040901Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of NaproxenAdriana Zeleňáková0Jaroslava Szűcsová1Ľuboš Nagy2Vladimír Girman3Vladimír Zeleňák4Veronika Huntošová5Institute of Physics, Pavol Jozef Šafárik University in Košice, Park Angelinum 9, 040 01 Košice, SlovakiaInstitute of Physics, Pavol Jozef Šafárik University in Košice, Park Angelinum 9, 040 01 Košice, SlovakiaInstitute of Physics, Pavol Jozef Šafárik University in Košice, Park Angelinum 9, 040 01 Košice, SlovakiaInstitute of Physics, Pavol Jozef Šafárik University in Košice, Park Angelinum 9, 040 01 Košice, SlovakiaInstitute of Chemistry, Pavol Jozef Šafárik University in Košice, Moyzesova 11, 040 01 Košice, SlovakiaCenter for Interdisciplinary Biosciences, Pavol Jozef Šafárik University in Košice, Jesenna 5, 040 01 Košice, SlovakiaIn this study, we describe the magnetic and structural properties and cytotoxicity of drug delivery composite (DDC) consisting of hexagonally ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe<sub>2</sub>O<sub>3</sub>), and the drug naproxen (Napro). The nonsteroidal anti-inflammatory drug (NSAID) naproxen was adsorbed into the pores of MCM-41 silica after the ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) encapsulation. Our results confirm the suppression of the Brownian relaxation process caused by a “gripping effect” since the rotation of the whole particle encapsulated in the porous system of mesoporous silica was disabled. This behavior was observed for the first time, to the best of our knowledge. Therefore, the dominant relaxation mechanism in powder and liquid form is the Néel process when the rotation of the nanoparticle’s magnetic moment is responsible for the relaxation. The in vitro cytotoxicity tests were performed using human glioma U87 MG cells, and the moderate manifestation of cell death, although at high concentrations of studied systems, was observed with fluorescent labeling by AnnexinV/FITC. All our results indicate that the as-prepared MCM-41/Napro/Fe<sub>2</sub>O<sub>3</sub> composite has a potential application as a drug nanocarrier for magnetic-targeted drug delivery.https://www.mdpi.com/2079-4991/11/4/901iron oxide magnetic nanoparticlescytotoxicity studydrug delivery |
| spellingShingle | Adriana Zeleňáková Jaroslava Szűcsová Ľuboš Nagy Vladimír Girman Vladimír Zeleňák Veronika Huntošová Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen Nanomaterials iron oxide magnetic nanoparticles cytotoxicity study drug delivery |
| title | Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen |
| title_full | Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen |
| title_fullStr | Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen |
| title_full_unstemmed | Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen |
| title_short | Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen |
| title_sort | magnetic characterization and moderate cytotoxicity of magnetic mesoporous silica nanocomposite for drug delivery of naproxen |
| topic | iron oxide magnetic nanoparticles cytotoxicity study drug delivery |
| url | https://www.mdpi.com/2079-4991/11/4/901 |
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