The Impact of Anti-Amyloid Immunotherapies on Stroke Care
Anti-amyloid immunotherapies have recently emerged as treatments for Alzheimer’s disease. While these therapies have demonstrated efficacy in clearing amyloid-β and slowing cognitive decline, they have also been associated with amyloid-related imaging abnormalities (ARIA) which include both edema (A...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/5/1245 |
| _version_ | 1797264330407804928 |
|---|---|
| author | Philippe A. Bilodeau John R. Dickson Mariel G. Kozberg |
| author_facet | Philippe A. Bilodeau John R. Dickson Mariel G. Kozberg |
| author_sort | Philippe A. Bilodeau |
| collection | DOAJ |
| description | Anti-amyloid immunotherapies have recently emerged as treatments for Alzheimer’s disease. While these therapies have demonstrated efficacy in clearing amyloid-β and slowing cognitive decline, they have also been associated with amyloid-related imaging abnormalities (ARIA) which include both edema (ARIA-E) and hemorrhage (ARIA-H). Given that ARIA have been associated with significant morbidity in cases of antithrombotic or thrombolytic therapy, an understanding of mechanisms of and risk factors for ARIA is of critical importance for stroke care. We discuss the latest data regarding mechanisms of ARIA, including the role of underlying cerebral amyloid angiopathy, and implications for ischemic stroke prevention and management. |
| first_indexed | 2024-04-25T00:27:11Z |
| format | Article |
| id | doaj.art-e38f823439bb4faeac8c1249c5f07fd9 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:27:11Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e38f823439bb4faeac8c1249c5f07fd92024-03-12T16:47:41ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135124510.3390/jcm13051245The Impact of Anti-Amyloid Immunotherapies on Stroke CarePhilippe A. Bilodeau0John R. Dickson1Mariel G. Kozberg2Division of Neuroimmunology and Neuroinfectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USAMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Boston, MA 02129, USAMassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Boston, MA 02129, USAAnti-amyloid immunotherapies have recently emerged as treatments for Alzheimer’s disease. While these therapies have demonstrated efficacy in clearing amyloid-β and slowing cognitive decline, they have also been associated with amyloid-related imaging abnormalities (ARIA) which include both edema (ARIA-E) and hemorrhage (ARIA-H). Given that ARIA have been associated with significant morbidity in cases of antithrombotic or thrombolytic therapy, an understanding of mechanisms of and risk factors for ARIA is of critical importance for stroke care. We discuss the latest data regarding mechanisms of ARIA, including the role of underlying cerebral amyloid angiopathy, and implications for ischemic stroke prevention and management.https://www.mdpi.com/2077-0383/13/5/1245anti-amyloid immunotherapyamyloid-related imaging abnormalitiesARIA-EARIA-Hcerebral amyloid angiopathyischemic stroke |
| spellingShingle | Philippe A. Bilodeau John R. Dickson Mariel G. Kozberg The Impact of Anti-Amyloid Immunotherapies on Stroke Care Journal of Clinical Medicine anti-amyloid immunotherapy amyloid-related imaging abnormalities ARIA-E ARIA-H cerebral amyloid angiopathy ischemic stroke |
| title | The Impact of Anti-Amyloid Immunotherapies on Stroke Care |
| title_full | The Impact of Anti-Amyloid Immunotherapies on Stroke Care |
| title_fullStr | The Impact of Anti-Amyloid Immunotherapies on Stroke Care |
| title_full_unstemmed | The Impact of Anti-Amyloid Immunotherapies on Stroke Care |
| title_short | The Impact of Anti-Amyloid Immunotherapies on Stroke Care |
| title_sort | impact of anti amyloid immunotherapies on stroke care |
| topic | anti-amyloid immunotherapy amyloid-related imaging abnormalities ARIA-E ARIA-H cerebral amyloid angiopathy ischemic stroke |
| url | https://www.mdpi.com/2077-0383/13/5/1245 |
| work_keys_str_mv | AT philippeabilodeau theimpactofantiamyloidimmunotherapiesonstrokecare AT johnrdickson theimpactofantiamyloidimmunotherapiesonstrokecare AT marielgkozberg theimpactofantiamyloidimmunotherapiesonstrokecare AT philippeabilodeau impactofantiamyloidimmunotherapiesonstrokecare AT johnrdickson impactofantiamyloidimmunotherapiesonstrokecare AT marielgkozberg impactofantiamyloidimmunotherapiesonstrokecare |