Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil
ABSTRACT Introduction: Recently, fasting flexibility for laboratory determination of lipid profile has been recommended. When triglycerides (TG) are above 400 mg/dl, the formula proposed by Martin et al. should be used to estimate the low-density lipoprotein cholesterol (LDL-C). However, this formu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2020-03-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100402&tlng=pt |
| _version_ | 1818951785269690368 |
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| author | Caio Mauricio M. Cordova Ariane S. Portal Maurício M. Cordova |
| author_facet | Caio Mauricio M. Cordova Ariane S. Portal Maurício M. Cordova |
| author_sort | Caio Mauricio M. Cordova |
| collection | DOAJ |
| description | ABSTRACT Introduction: Recently, fasting flexibility for laboratory determination of lipid profile has been recommended. When triglycerides (TG) are above 400 mg/dl, the formula proposed by Martin et al. should be used to estimate the low-density lipoprotein cholesterol (LDL-C). However, this formula has not been evaluated in our population. Objectives: We evaluated the performance of Martin’s equation for LDL-C estimation compared to Cordova & Cordova and Friedewald formulas in a population of Southern Brazil. Methods: Sampling consisted of 10,664 Brazilian individuals (5,847 women) aged 1 to 93 years, with TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C directly measured. Results: Martin’s formula presented significantly higher LDL-C values in patients with TG < 300 mg/dl, underestimating values when TG > 400 mg/dl, even with negative values; and LDL-C values was also overestimated in all TC ranges, with greater standard deviation. It also presented a higher mean error in the stratified intervals, and a lower correlation coefficient. Conclusion: Martin’s equation is not accurate for estimating LDL-C in our sample, unless TG is between 300 and 400 mg/dl. We recommend using the Cordova & Cordova formula as an alternative to determine LDL-C when its direct measurement is not available, and not applying the Martin’s Formula indiscriminately to other populations before it is properly evaluated and compared with other available equations. |
| first_indexed | 2024-12-20T09:40:00Z |
| format | Article |
| id | doaj.art-e3941fd7be084884aedc0733f1c283f6 |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-20T09:40:00Z |
| publishDate | 2020-03-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-e3941fd7be084884aedc0733f1c283f62022-12-21T19:44:55ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742020-03-015610.5935/1676-2444.20200003Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern BrazilCaio Mauricio M. Cordovahttps://orcid.org/0000-0001-6090-0367Ariane S. PortalMaurício M. CordovaABSTRACT Introduction: Recently, fasting flexibility for laboratory determination of lipid profile has been recommended. When triglycerides (TG) are above 400 mg/dl, the formula proposed by Martin et al. should be used to estimate the low-density lipoprotein cholesterol (LDL-C). However, this formula has not been evaluated in our population. Objectives: We evaluated the performance of Martin’s equation for LDL-C estimation compared to Cordova & Cordova and Friedewald formulas in a population of Southern Brazil. Methods: Sampling consisted of 10,664 Brazilian individuals (5,847 women) aged 1 to 93 years, with TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and LDL-C directly measured. Results: Martin’s formula presented significantly higher LDL-C values in patients with TG < 300 mg/dl, underestimating values when TG > 400 mg/dl, even with negative values; and LDL-C values was also overestimated in all TC ranges, with greater standard deviation. It also presented a higher mean error in the stratified intervals, and a lower correlation coefficient. Conclusion: Martin’s equation is not accurate for estimating LDL-C in our sample, unless TG is between 300 and 400 mg/dl. We recommend using the Cordova & Cordova formula as an alternative to determine LDL-C when its direct measurement is not available, and not applying the Martin’s Formula indiscriminately to other populations before it is properly evaluated and compared with other available equations.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100402&tlng=ptcholesterolLDL-cholesterolformulaatherosclerosisrisk factor. |
| spellingShingle | Caio Mauricio M. Cordova Ariane S. Portal Maurício M. Cordova Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil Jornal Brasileiro de Patologia e Medicina Laboratorial cholesterol LDL-cholesterol formula atherosclerosis risk factor. |
| title | Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil |
| title_full | Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil |
| title_fullStr | Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil |
| title_full_unstemmed | Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil |
| title_short | Martin's, Friedewald's and Cordova's formulas compared to LDL-C directly measured in Southern Brazil |
| title_sort | martin s friedewald s and cordova s formulas compared to ldl c directly measured in southern brazil |
| topic | cholesterol LDL-cholesterol formula atherosclerosis risk factor. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442020000100402&tlng=pt |
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