THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA
Recent research revealed dendritic cells (DCs) to have direct antitumor cytotoxic activity and to inhibit the growth and proliferation of tumor cells in vitro. The aim of the present study was to investigate the association between the cytotoxic activity of dendritic cells generated in the presence...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/152 |
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| author | T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova D. S. Batorova G. Yu. Ushakova V. V. Sergeevicheva S. A. Sizikova I. V. Kryuchkova A. A. Ostanin E. R. Chernykh |
| author_facet | T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova D. S. Batorova G. Yu. Ushakova V. V. Sergeevicheva S. A. Sizikova I. V. Kryuchkova A. A. Ostanin E. R. Chernykh |
| author_sort | T. V. Tyrinova |
| collection | DOAJ |
| description | Recent research revealed dendritic cells (DCs) to have direct antitumor cytotoxic activity and to inhibit the growth and proliferation of tumor cells in vitro. The aim of the present study was to investigate the association between the cytotoxic activity of dendritic cells generated in the presence of interferon alpha (IFN-DCs) and TNFα expression by IFN-DCs in patients with malignant lymphomas. It was shown that IFN-DCs of malignant lymphoma patients possessed low cytotoxic activity against tumor cell line HEp-2 associated with low expression of transmembrane TNFα (tmTNFα) and high level of soluble TNFα (sTNFα) secretion. Reduced DC cytotoxic activity and low tmTNFα expression on DC surface were observed mainly in Hodgkin’s lymphoma patients. In contrast, IFN-DCs of patients with non-Hodgkin lymphoma were endowed with the ability to lysis of HEp-2 cells and tmTNFα molecule expression was similar to that in IFN-DCs from healthy donors. It was determined that the increase of expression of tmTNFα molecule on lymphoma patient IFN-DCs induced by the addition of TNFα-converting enzyme inhibitor into IFN-DC cultures was associated with the enhancement of IFN-DC cytotoxic activity against HEp-2 cells. |
| first_indexed | 2024-04-10T01:54:50Z |
| format | Article |
| id | doaj.art-e39420cb8732403e85caf8d8aea200d0 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:54:50Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-e39420cb8732403e85caf8d8aea200d02023-03-13T09:05:47ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01155158152THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHAT. V. Tyrinova0O. Yu. Leplina1M. A. Tikhonova2D. S. Batorova3G. Yu. Ushakova4V. V. Sergeevicheva5S. A. Sizikova6I. V. Kryuchkova7A. A. Ostanin8E. R. Chernykh9НИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскНИИ фундаментальной и клинической иммунологии, НовосибирскRecent research revealed dendritic cells (DCs) to have direct antitumor cytotoxic activity and to inhibit the growth and proliferation of tumor cells in vitro. The aim of the present study was to investigate the association between the cytotoxic activity of dendritic cells generated in the presence of interferon alpha (IFN-DCs) and TNFα expression by IFN-DCs in patients with malignant lymphomas. It was shown that IFN-DCs of malignant lymphoma patients possessed low cytotoxic activity against tumor cell line HEp-2 associated with low expression of transmembrane TNFα (tmTNFα) and high level of soluble TNFα (sTNFα) secretion. Reduced DC cytotoxic activity and low tmTNFα expression on DC surface were observed mainly in Hodgkin’s lymphoma patients. In contrast, IFN-DCs of patients with non-Hodgkin lymphoma were endowed with the ability to lysis of HEp-2 cells and tmTNFα molecule expression was similar to that in IFN-DCs from healthy donors. It was determined that the increase of expression of tmTNFα molecule on lymphoma patient IFN-DCs induced by the addition of TNFα-converting enzyme inhibitor into IFN-DC cultures was associated with the enhancement of IFN-DC cytotoxic activity against HEp-2 cells.https://www.siboncoj.ru/jour/article/view/152дендритные клетки, интерферон альфа,злокачественные лимфомы, фактор некроза опухоли альфа |
| spellingShingle | T. V. Tyrinova O. Yu. Leplina M. A. Tikhonova D. S. Batorova G. Yu. Ushakova V. V. Sergeevicheva S. A. Sizikova I. V. Kryuchkova A. A. Ostanin E. R. Chernykh THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA Сибирский онкологический журнал дендритные клетки, интерферон альфа,злокачественные лимфомы, фактор некроза опухоли альфа |
| title | THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA |
| title_full | THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA |
| title_fullStr | THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA |
| title_full_unstemmed | THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA |
| title_short | THE IMPAIRMENT OF ANTITUMOR CYTOTOXIC ACTIVITY OF DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA DUE TO THE ALTERED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA |
| title_sort | impairment of antitumor cytotoxic activity of dendritic cells in patients with malignant lymphoma due to the altered expression of tumor necrosis factor alpha |
| topic | дендритные клетки, интерферон альфа,злокачественные лимфомы, фактор некроза опухоли альфа |
| url | https://www.siboncoj.ru/jour/article/view/152 |
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