Retinal vasculitis following intravitreal pegcetacoplan administration
Purpose: To describe a case of retinal vaso-occlusive vasculitis with associated lid edema and conjunctivitis following intravitreal pegcetacoplan administration in a patient with geographic atrophy (GA). Observation: A 78 year old Caucasian woman presented with complaints of lid edema, conjunctival...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624000094 |
| _version_ | 1797301421519929344 |
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| author | Stella Douros David Mostafavi Mary Danias |
| author_facet | Stella Douros David Mostafavi Mary Danias |
| author_sort | Stella Douros |
| collection | DOAJ |
| description | Purpose: To describe a case of retinal vaso-occlusive vasculitis with associated lid edema and conjunctivitis following intravitreal pegcetacoplan administration in a patient with geographic atrophy (GA). Observation: A 78 year old Caucasian woman presented with complaints of lid edema, conjunctival injection, loss of vision, and mild ocular discomfort eleven days after receiving an intravitreal pegcetacoplan injection in the left eye for geographic atrophy. Visual acuity on presentation was decreased to 20/400 from 20/200 previously in that eye. Eyelid edema and conjunctival injection were present with minimal anterior chamber reaction. Dilated fundus examination revealed hemorrhages throughout the retina and signs of retinal vasculitis. The patient subsequently developed hyphema and vitreous hemorrhage. Laboratory evaluations for common infectious and inflammatory causes including aqueous and vitreous cultures for bacteria and Herpes simplex PCR were normal or negative. A delayed hypersensitivity to pegcetacoplan was suspected and was treated with topical, oral subconjunctival and intravitreal steroids. Conclusion: This index report illustrates a case of retinal vaso-occlusive vasculitis associated with intravitreal pegcetacoplan associated with lid edema and conjunctival injection and subsequent hyphema and vitreous hemorrhage. Therapy with steroids topically, systemically, periocularly and intravitreally were used to treat the inflammatory process and prevent further visual loss. |
| first_indexed | 2024-03-07T23:22:20Z |
| format | Article |
| id | doaj.art-e395d72b8e87490ca4c99c9959c8e6db |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-03-07T23:22:20Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-e395d72b8e87490ca4c99c9959c8e6db2024-02-21T05:29:22ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362024-03-0133101999Retinal vasculitis following intravitreal pegcetacoplan administrationStella Douros0David Mostafavi1Mary Danias2Stella Douros, M.D., P.C., Brooklyn, NY, USA; SUNY Downstate Medical Center, Brooklyn, NY, USA; Corresponding author. Stella Douros, M.D., P.C., Brooklyn, NY, USA.SUNY Downstate Medical Center, Brooklyn, NY, USA; Mostafavi Eye Institute, Staten Island, NY, USANortheastern University, Boston, MA, USAPurpose: To describe a case of retinal vaso-occlusive vasculitis with associated lid edema and conjunctivitis following intravitreal pegcetacoplan administration in a patient with geographic atrophy (GA). Observation: A 78 year old Caucasian woman presented with complaints of lid edema, conjunctival injection, loss of vision, and mild ocular discomfort eleven days after receiving an intravitreal pegcetacoplan injection in the left eye for geographic atrophy. Visual acuity on presentation was decreased to 20/400 from 20/200 previously in that eye. Eyelid edema and conjunctival injection were present with minimal anterior chamber reaction. Dilated fundus examination revealed hemorrhages throughout the retina and signs of retinal vasculitis. The patient subsequently developed hyphema and vitreous hemorrhage. Laboratory evaluations for common infectious and inflammatory causes including aqueous and vitreous cultures for bacteria and Herpes simplex PCR were normal or negative. A delayed hypersensitivity to pegcetacoplan was suspected and was treated with topical, oral subconjunctival and intravitreal steroids. Conclusion: This index report illustrates a case of retinal vaso-occlusive vasculitis associated with intravitreal pegcetacoplan associated with lid edema and conjunctival injection and subsequent hyphema and vitreous hemorrhage. Therapy with steroids topically, systemically, periocularly and intravitreally were used to treat the inflammatory process and prevent further visual loss.http://www.sciencedirect.com/science/article/pii/S2451993624000094Occlusive vasculitisRetinal vasculitisPegcetacoplanGeographic atrophyLid edemaConjunctivitis |
| spellingShingle | Stella Douros David Mostafavi Mary Danias Retinal vasculitis following intravitreal pegcetacoplan administration American Journal of Ophthalmology Case Reports Occlusive vasculitis Retinal vasculitis Pegcetacoplan Geographic atrophy Lid edema Conjunctivitis |
| title | Retinal vasculitis following intravitreal pegcetacoplan administration |
| title_full | Retinal vasculitis following intravitreal pegcetacoplan administration |
| title_fullStr | Retinal vasculitis following intravitreal pegcetacoplan administration |
| title_full_unstemmed | Retinal vasculitis following intravitreal pegcetacoplan administration |
| title_short | Retinal vasculitis following intravitreal pegcetacoplan administration |
| title_sort | retinal vasculitis following intravitreal pegcetacoplan administration |
| topic | Occlusive vasculitis Retinal vasculitis Pegcetacoplan Geographic atrophy Lid edema Conjunctivitis |
| url | http://www.sciencedirect.com/science/article/pii/S2451993624000094 |
| work_keys_str_mv | AT stelladouros retinalvasculitisfollowingintravitrealpegcetacoplanadministration AT davidmostafavi retinalvasculitisfollowingintravitrealpegcetacoplanadministration AT marydanias retinalvasculitisfollowingintravitrealpegcetacoplanadministration |