An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment
The occurrence and development of atherosclerosis could be influenced by intermittent hypoxia. Obstructive sleep apnea (OSA), characterized by intermittent hypoxia, is world-wide prevalence with increasing morbidity and mortality rates. Researches remain focused on the study of its mechanism and imp...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.647071/full |
| _version_ | 1819067968767655936 |
|---|---|
| author | Jin Chen Shu Lin Shu Lin Yiming Zeng |
| author_facet | Jin Chen Shu Lin Shu Lin Yiming Zeng |
| author_sort | Jin Chen |
| collection | DOAJ |
| description | The occurrence and development of atherosclerosis could be influenced by intermittent hypoxia. Obstructive sleep apnea (OSA), characterized by intermittent hypoxia, is world-wide prevalence with increasing morbidity and mortality rates. Researches remain focused on the study of its mechanism and improvement of diagnosis and treatment. However, the underlying mechanism is complex, and the best practice for OSA diagnosis and treatment considering atherosclerosis and related cardiovascular diseases is still debatable. In this review, we provided an update on research in OSA in the last 5 years with regard to atherosclerosis. The processes of inflammation, oxidative stress, autonomic nervous system activation, vascular dysfunction, platelet activation, metabolite dysfunction, small molecule RNA regulation, and the cardioprotective occurrence was discussed. Additionally, improved diagnosis such as, the utilized of portable device, and treatment especially with inconsistent results in continuous positive airway pressure and mandibular advancement devices were illustrated in detail. Therefore, further fundamental and clinical research should be carried out for a better understanding the deep interaction between OSA and atherosclerosis, as well as the suggestion of newer diagnostic and treatment options. |
| first_indexed | 2024-12-21T16:26:41Z |
| format | Article |
| id | doaj.art-e396eae56f1342f79c1f3972f0a846bf |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-21T16:26:41Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e396eae56f1342f79c1f3972f0a846bf2022-12-21T18:57:26ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-04-01810.3389/fcvm.2021.647071647071An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and TreatmentJin Chen0Shu Lin1Shu Lin2Yiming Zeng3Clinical Center for Molecular Diagnosis and Therapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaCentre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaDepartment of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Respiratory Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, ChinaThe occurrence and development of atherosclerosis could be influenced by intermittent hypoxia. Obstructive sleep apnea (OSA), characterized by intermittent hypoxia, is world-wide prevalence with increasing morbidity and mortality rates. Researches remain focused on the study of its mechanism and improvement of diagnosis and treatment. However, the underlying mechanism is complex, and the best practice for OSA diagnosis and treatment considering atherosclerosis and related cardiovascular diseases is still debatable. In this review, we provided an update on research in OSA in the last 5 years with regard to atherosclerosis. The processes of inflammation, oxidative stress, autonomic nervous system activation, vascular dysfunction, platelet activation, metabolite dysfunction, small molecule RNA regulation, and the cardioprotective occurrence was discussed. Additionally, improved diagnosis such as, the utilized of portable device, and treatment especially with inconsistent results in continuous positive airway pressure and mandibular advancement devices were illustrated in detail. Therefore, further fundamental and clinical research should be carried out for a better understanding the deep interaction between OSA and atherosclerosis, as well as the suggestion of newer diagnostic and treatment options.https://www.frontiersin.org/articles/10.3389/fcvm.2021.647071/fullobstructive sleep apneaatherosclerosishypoxiamechanismtreatment |
| spellingShingle | Jin Chen Shu Lin Shu Lin Yiming Zeng An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment Frontiers in Cardiovascular Medicine obstructive sleep apnea atherosclerosis hypoxia mechanism treatment |
| title | An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment |
| title_full | An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment |
| title_fullStr | An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment |
| title_full_unstemmed | An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment |
| title_short | An Update on Obstructive Sleep Apnea for Atherosclerosis: Mechanism, Diagnosis, and Treatment |
| title_sort | update on obstructive sleep apnea for atherosclerosis mechanism diagnosis and treatment |
| topic | obstructive sleep apnea atherosclerosis hypoxia mechanism treatment |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.647071/full |
| work_keys_str_mv | AT jinchen anupdateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT shulin anupdateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT shulin anupdateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT yimingzeng anupdateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT jinchen updateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT shulin updateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT shulin updateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment AT yimingzeng updateonobstructivesleepapneaforatherosclerosismechanismdiagnosisandtreatment |