Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation
The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6532 |
| _version_ | 1797486600421113856 |
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| author | Lidia La Barbera Federica Macaluso Serena Fasano Giulia Grasso Francesco Ciccia Giuliana Guggino |
| author_facet | Lidia La Barbera Federica Macaluso Serena Fasano Giulia Grasso Francesco Ciccia Giuliana Guggino |
| author_sort | Lidia La Barbera |
| collection | DOAJ |
| description | The microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system. |
| first_indexed | 2024-03-09T23:35:33Z |
| format | Article |
| id | doaj.art-e398be26546541b5a7bc70ec5a185fd4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:35:33Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e398be26546541b5a7bc70ec5a185fd42023-11-23T17:02:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312653210.3390/ijms23126532Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and InflammationLidia La Barbera0Federica Macaluso1Serena Fasano2Giulia Grasso3Francesco Ciccia4Giuliana Guggino5Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, Piazza delle Cliniche 2, 90110 Palermo, ItalyRheumatology Unit, Department of Internal Medicine, University of Modena and Reggio Emilia, AUSL-IRCCS, Via Giovanni Amendola, 2, 42122 Reggio Emilia, ItalyDivision of Rheumatology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, S. Andrea delle Dame, Via L. De Crecchio 7, 80138 Naples, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, Piazza delle Cliniche 2, 90110 Palermo, ItalyDivision of Rheumatology, Department of Precision Medicine, University of Campania Luigi Vanvitelli, S. Andrea delle Dame, Via L. De Crecchio 7, 80138 Naples, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, Piazza delle Cliniche 2, 90110 Palermo, ItalyThe microbial community acts as an active player in maintaining homeostasis and immune functions through a continuous and changeable cross-talk with the host immune system. Emerging evidence suggests that altered microbial composition, known as dysbiosis, might perturb the delicate balance between the microbiota and the immune system, triggering inflammation and potentially contributing to the pathogenesis and development of chronic inflammatory diseases. This review will summarize the current evidence about the microbiome-immunity cross-talk, especially focusing on the microbiota alterations described in patients with rheumatic diseases and on the recent findings concerning the interaction between microbiota, metabolic function, and the immune system.https://www.mdpi.com/1422-0067/23/12/6532microbiomedysbiosisinflammationchronic immune-mediated inflammatory diseases |
| spellingShingle | Lidia La Barbera Federica Macaluso Serena Fasano Giulia Grasso Francesco Ciccia Giuliana Guggino Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation International Journal of Molecular Sciences microbiome dysbiosis inflammation chronic immune-mediated inflammatory diseases |
| title | Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation |
| title_full | Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation |
| title_fullStr | Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation |
| title_full_unstemmed | Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation |
| title_short | Microbiome Changes in Connective Tissue Diseases and Vasculitis: Focus on Metabolism and Inflammation |
| title_sort | microbiome changes in connective tissue diseases and vasculitis focus on metabolism and inflammation |
| topic | microbiome dysbiosis inflammation chronic immune-mediated inflammatory diseases |
| url | https://www.mdpi.com/1422-0067/23/12/6532 |
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