Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study
Introduction: Cutaneous adverse drug reactions (CADRs) are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated. Aim and Objectives: To study the morphological patterns of various types of CADRs. Materials and Methods: It wa...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Drugs in Dermatology |
| Subjects: | |
| Online Access: | http://www.ijdd.in/article.asp?issn=2455-3972;year=2023;volume=9;issue=1;spage=28;epage=33;aulast=Roge |
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| author | Rakesh P Roge Jayesh Ishwardas Mukhi Sudhir M Mamidwar Pallavi Rupkumar Rokade Bhagyashree Babanrao Supekar |
| author_facet | Rakesh P Roge Jayesh Ishwardas Mukhi Sudhir M Mamidwar Pallavi Rupkumar Rokade Bhagyashree Babanrao Supekar |
| author_sort | Rakesh P Roge |
| collection | DOAJ |
| description | Introduction: Cutaneous adverse drug reactions (CADRs) are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated. Aim and Objectives: To study the morphological patterns of various types of CADRs. Materials and Methods: It was a descriptive cross-sectional study carried out from November 2017 to September 2019, where medical records of diagnosed cases of CADRs were analyzed in a predesigned proforma with respect to demographic data, clinical features, treatment history (topical and oral), offending drug, temporal association with a skin eruption, investigations, and treatment outcome. Statistical analysis was done using mean, median, and proportion. Results: A total of 180 patients with CADRs were enrolled. There was a male preponderance with the mean age being 32.9 ± 2.9 years. The most common CADR reported was fixed drug eruption (n = 77). Steven Johnson syndrome was the most common (n = 7) severe cutaneous adverse reaction. The mean duration of latency was 6.2 (±8.61 days). Antimicrobial drugs accounted for most of the benign as well as severe CADRs (41.4%). Among all cases, 43.9% of patients had mild CADR and 16.7% had severe CADR. Causality assessment using the Naranjo adverse drug reaction probability scale, 70% had a possible association, 18.3% probable and 11.7% had a doubtful association. Conclusion: Early identification of CADR is important to reduce morbidity and mortality. Patient education is required to avoid self-administration of drugs and re-administration of the same offending drugs to prevent further morbidity. Immediate withdrawal of the culprit drug/drugs with adequate management can be lifesaving. |
| first_indexed | 2024-03-11T15:45:35Z |
| format | Article |
| id | doaj.art-e398dc2aea45404ba1b1da5db9ac1a76 |
| institution | Directory Open Access Journal |
| issn | 2455-3972 |
| language | English |
| last_indexed | 2024-03-11T15:45:35Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Drugs in Dermatology |
| spelling | doaj.art-e398dc2aea45404ba1b1da5db9ac1a762023-10-26T06:38:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Drugs in Dermatology2455-39722023-01-0191283310.4103/ijdd.ijdd_25_23Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional studyRakesh P RogeJayesh Ishwardas MukhiSudhir M MamidwarPallavi Rupkumar RokadeBhagyashree Babanrao SupekarIntroduction: Cutaneous adverse drug reactions (CADRs) are the most common adverse reactions attributed to drugs in which any type of skin reaction can be mimicked, induced, or aggravated. Aim and Objectives: To study the morphological patterns of various types of CADRs. Materials and Methods: It was a descriptive cross-sectional study carried out from November 2017 to September 2019, where medical records of diagnosed cases of CADRs were analyzed in a predesigned proforma with respect to demographic data, clinical features, treatment history (topical and oral), offending drug, temporal association with a skin eruption, investigations, and treatment outcome. Statistical analysis was done using mean, median, and proportion. Results: A total of 180 patients with CADRs were enrolled. There was a male preponderance with the mean age being 32.9 ± 2.9 years. The most common CADR reported was fixed drug eruption (n = 77). Steven Johnson syndrome was the most common (n = 7) severe cutaneous adverse reaction. The mean duration of latency was 6.2 (±8.61 days). Antimicrobial drugs accounted for most of the benign as well as severe CADRs (41.4%). Among all cases, 43.9% of patients had mild CADR and 16.7% had severe CADR. Causality assessment using the Naranjo adverse drug reaction probability scale, 70% had a possible association, 18.3% probable and 11.7% had a doubtful association. Conclusion: Early identification of CADR is important to reduce morbidity and mortality. Patient education is required to avoid self-administration of drugs and re-administration of the same offending drugs to prevent further morbidity. Immediate withdrawal of the culprit drug/drugs with adequate management can be lifesaving.http://www.ijdd.in/article.asp?issn=2455-3972;year=2023;volume=9;issue=1;spage=28;epage=33;aulast=Rogeacneiform eruptioncentral indiacutaneous adverse drug reactionfixed drug eruption |
| spellingShingle | Rakesh P Roge Jayesh Ishwardas Mukhi Sudhir M Mamidwar Pallavi Rupkumar Rokade Bhagyashree Babanrao Supekar Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study Indian Journal of Drugs in Dermatology acneiform eruption central india cutaneous adverse drug reaction fixed drug eruption |
| title | Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study |
| title_full | Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study |
| title_fullStr | Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study |
| title_full_unstemmed | Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study |
| title_short | Clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central India: A cross-sectional study |
| title_sort | clinical patterns of cutaneous adverse drug reactions in tertiary care centre of central india a cross sectional study |
| topic | acneiform eruption central india cutaneous adverse drug reaction fixed drug eruption |
| url | http://www.ijdd.in/article.asp?issn=2455-3972;year=2023;volume=9;issue=1;spage=28;epage=33;aulast=Roge |
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