Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin
OBJECTIVE: Emesis is a critical adverse effect of cancer treatment. In this study, prophylactic activity of ondansetron (OND), tropisetron (TRO) and granisetron (GRA) on acute emesis following carboplatinpaclitaxel chemotherapy was compared. STUDY DESIGN: Charts of 277 patients, who had been treated...
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| Format: | Article |
| Language: | English |
| Published: |
Medical Network
2007-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
| Subjects: | |
| Online Access: | http://gorm.com.tr/index.php/GORM/article/view/526 |
| _version_ | 1828024326049234944 |
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| author | Taner Turan Serap Bozok Nihal Erdoğan Özlem Karaçay Gökhan Tulunay Nurettin Boran İskender Kög Faruk Köse |
| author_facet | Taner Turan Serap Bozok Nihal Erdoğan Özlem Karaçay Gökhan Tulunay Nurettin Boran İskender Kög Faruk Köse |
| author_sort | Taner Turan |
| collection | DOAJ |
| description | OBJECTIVE: Emesis is a critical adverse effect of cancer treatment. In this study, prophylactic activity of ondansetron (OND), tropisetron (TRO) and granisetron (GRA) on acute emesis following carboplatinpaclitaxel chemotherapy was compared.
STUDY DESIGN: Charts of 277 patients, who had been treated with first-line carboplatin-paclitaxel combined chemotherapy after being operated with a diagnosis of gynecologic malignancy in between 1993 and 2005, were evaluated retrospectively. After premedication, chemotherapy was initiated with paclitaxel
175 mg/m², infused in three hours. Then, carboplatin was infused in one hour (AUC=6). 90 minutes before the onset of chemotherapy, dexamethasone, 24 mg was infused within an hour. 5 HT3 receptor antagonist (OND=8 mg / TRO=5 mg / GRA=3 mg) were infused for a duration of 30 minutes, one hour before the chemotherapy. Toxicity was evaluated according to WHO criteria. Grade 0 toxicity
was accepted as complete response, grade 1 and higher toxicity was accepted unresponsive.
RESULTS: The mean age was 55 years. Overall 1582 courses of chemotherapy were given. 241 patients (87%) received six courses. OND was given to 57 (20.6%) patients at 321 (20.3%) courses, TRO to 57 (20.6%) patients at 330 (20.9%) courses and GRA to 163 (58.8%) patients at 931 (58.8%) courses. Grade 3-4 toxicity did not develop in any of the patients. Complete response was achieved in
41.2% of the patients in 77.1% of the cycles. Antiemetic activities of TRO and GRA were stronger than OND.
CONCLUSION: Even though this study was retrospective, the treatment and patient groups were homogeneous. Both the discovery of an antiemetic that is much more effective and a protocol that is improved are essential. An emerging need for prospective studies achieved with homogeneous patient groups does exist. |
| first_indexed | 2024-04-10T12:42:17Z |
| format | Article |
| id | doaj.art-e39c40fbf3be4a0eb5ae4cdd9807848f |
| institution | Directory Open Access Journal |
| issn | 1300-4751 |
| language | English |
| last_indexed | 2024-04-10T12:42:17Z |
| publishDate | 2007-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj.art-e39c40fbf3be4a0eb5ae4cdd9807848f2023-02-15T16:14:14ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512007-08-01132460Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and CarboplatinTaner Turan0Serap Bozok1Nihal Erdoğan2Özlem Karaçay3Gökhan Tulunay4Nurettin Boran5İskender Kög6Faruk Köse7Ankara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraAnkara Etlik Maternity and Women’s Health Teaching Hospital Gynecologic Oncology Division, AnkaraOBJECTIVE: Emesis is a critical adverse effect of cancer treatment. In this study, prophylactic activity of ondansetron (OND), tropisetron (TRO) and granisetron (GRA) on acute emesis following carboplatinpaclitaxel chemotherapy was compared. STUDY DESIGN: Charts of 277 patients, who had been treated with first-line carboplatin-paclitaxel combined chemotherapy after being operated with a diagnosis of gynecologic malignancy in between 1993 and 2005, were evaluated retrospectively. After premedication, chemotherapy was initiated with paclitaxel 175 mg/m², infused in three hours. Then, carboplatin was infused in one hour (AUC=6). 90 minutes before the onset of chemotherapy, dexamethasone, 24 mg was infused within an hour. 5 HT3 receptor antagonist (OND=8 mg / TRO=5 mg / GRA=3 mg) were infused for a duration of 30 minutes, one hour before the chemotherapy. Toxicity was evaluated according to WHO criteria. Grade 0 toxicity was accepted as complete response, grade 1 and higher toxicity was accepted unresponsive. RESULTS: The mean age was 55 years. Overall 1582 courses of chemotherapy were given. 241 patients (87%) received six courses. OND was given to 57 (20.6%) patients at 321 (20.3%) courses, TRO to 57 (20.6%) patients at 330 (20.9%) courses and GRA to 163 (58.8%) patients at 931 (58.8%) courses. Grade 3-4 toxicity did not develop in any of the patients. Complete response was achieved in 41.2% of the patients in 77.1% of the cycles. Antiemetic activities of TRO and GRA were stronger than OND. CONCLUSION: Even though this study was retrospective, the treatment and patient groups were homogeneous. Both the discovery of an antiemetic that is much more effective and a protocol that is improved are essential. An emerging need for prospective studies achieved with homogeneous patient groups does exist.http://gorm.com.tr/index.php/GORM/article/view/526Carboplatin, Emesis, 5 HT3 receptor antagonists |
| spellingShingle | Taner Turan Serap Bozok Nihal Erdoğan Özlem Karaçay Gökhan Tulunay Nurettin Boran İskender Kög Faruk Köse Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin Gynecology Obstetrics & Reproductive Medicine Carboplatin, Emesis, 5 HT3 receptor antagonists |
| title | Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin |
| title_full | Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin |
| title_fullStr | Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin |
| title_full_unstemmed | Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin |
| title_short | Comparison of Antiemetic Effects of Ondansetron Granisetron and Tropisetron For Acute Emesis In Ovarian Cancer Patients Receiving Chemotherapy With Paclitaxel and Carboplatin |
| title_sort | comparison of antiemetic effects of ondansetron granisetron and tropisetron for acute emesis in ovarian cancer patients receiving chemotherapy with paclitaxel and carboplatin |
| topic | Carboplatin, Emesis, 5 HT3 receptor antagonists |
| url | http://gorm.com.tr/index.php/GORM/article/view/526 |
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