The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome
Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of exocrine glands including salivary and lachrymal glands responsible for the classical dry eyes and mouth symptoms (sicca syndrome). The spectrum of disease manifestations stretches beyond the classical sicca...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/2/658 |
| _version_ | 1797413084313157632 |
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| author | Clara Chivasso Julie Sarrand Jason Perret Christine Delporte Muhammad Shahnawaz Soyfoo |
| author_facet | Clara Chivasso Julie Sarrand Jason Perret Christine Delporte Muhammad Shahnawaz Soyfoo |
| author_sort | Clara Chivasso |
| collection | DOAJ |
| description | Sjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of exocrine glands including salivary and lachrymal glands responsible for the classical dry eyes and mouth symptoms (sicca syndrome). The spectrum of disease manifestations stretches beyond the classical sicca syndrome with systemic manifestations including arthritis, interstitial lung involvement, and neurological involvement. The pathophysiology underlying SS is not well deciphered, but several converging lines of evidence have supported the conjuncture of different factors interplaying together to foster the initiation and perpetuation of the disease. The innate and adaptive immune system play a cardinal role in this process. In this review, we discuss the inherent parts played by both the innate and adaptive immune system in the pathogenesis of SS. |
| first_indexed | 2024-03-09T05:12:27Z |
| format | Article |
| id | doaj.art-e39d1a5db35941978796fafbed086a47 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:12:27Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e39d1a5db35941978796fafbed086a472023-12-03T12:48:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122265810.3390/ijms22020658The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s SyndromeClara Chivasso0Julie Sarrand1Jason Perret2Christine Delporte3Muhammad Shahnawaz Soyfoo4Laboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumLaboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, BelgiumLaboratory of Pathophysiological and Nutritional Biochemistry, Université Libre de Bruxelles, 1070 Brussels, BelgiumDepartment of Rheumatology, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, BelgiumSjogren’s syndrome (SS) is a chronic autoimmune disease characterized by the infiltration of exocrine glands including salivary and lachrymal glands responsible for the classical dry eyes and mouth symptoms (sicca syndrome). The spectrum of disease manifestations stretches beyond the classical sicca syndrome with systemic manifestations including arthritis, interstitial lung involvement, and neurological involvement. The pathophysiology underlying SS is not well deciphered, but several converging lines of evidence have supported the conjuncture of different factors interplaying together to foster the initiation and perpetuation of the disease. The innate and adaptive immune system play a cardinal role in this process. In this review, we discuss the inherent parts played by both the innate and adaptive immune system in the pathogenesis of SS.https://www.mdpi.com/1422-0067/22/2/658sjogren’s syndromeepithelial cellsinnate immunitylymphocytest cellsb cells |
| spellingShingle | Clara Chivasso Julie Sarrand Jason Perret Christine Delporte Muhammad Shahnawaz Soyfoo The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome International Journal of Molecular Sciences sjogren’s syndrome epithelial cells innate immunity lymphocytes t cells b cells |
| title | The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome |
| title_full | The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome |
| title_fullStr | The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome |
| title_full_unstemmed | The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome |
| title_short | The Involvement of Innate and Adaptive Immunity in the Initiation and Perpetuation of Sjögren’s Syndrome |
| title_sort | involvement of innate and adaptive immunity in the initiation and perpetuation of sjogren s syndrome |
| topic | sjogren’s syndrome epithelial cells innate immunity lymphocytes t cells b cells |
| url | https://www.mdpi.com/1422-0067/22/2/658 |
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