Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model
Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish fo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Toxicology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750019301647 |
| _version_ | 1819276371095977984 |
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| author | Tamanna Kabir Saeed Anwar Jarin Taslem Mourosi Jakir Hossain Md. Golam Rabbane Md. Masuder Rahman Tohura Tahsin Md. Nazmul Hasan Manik Chandra Shill Mohammad Jakir Hosen |
| author_facet | Tamanna Kabir Saeed Anwar Jarin Taslem Mourosi Jakir Hossain Md. Golam Rabbane Md. Masuder Rahman Tohura Tahsin Md. Nazmul Hasan Manik Chandra Shill Mohammad Jakir Hosen |
| author_sort | Tamanna Kabir |
| collection | DOAJ |
| description | Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish followed by comprehensive microscopic analysis was conducted to study the embryonic development after exposure to different concentrations of arsenic ranges from 4−120 h post-fertilization. Zebrafish embryos exposed to 2 mM of arsenic displayed distinguishable developmental delay compared to control. At three days post-fertilization, a distinct phenotype appears in arsenic-treated embryos, which can be characterized by dechorionated embryos, larger egg mass, pericardial edema, abnormal heart rate, and abnormal head development. Remarkably, the death rate of the arsenic-treated embryos was significantly higher compared to control. Collectively, these findings indicate that exposure to arsenic may result in abnormal embryonic development. These results suggest for proper management of the pregnant mother in the arsenic-exposed area, and may also explain the incidence of increased miscarriage/abortion rate in arsenic water drinking pregnant mother. |
| first_indexed | 2024-12-23T23:39:09Z |
| format | Article |
| id | doaj.art-e39d4c7d168c47c59c7123ea13c18cae |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-23T23:39:09Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-e39d4c7d168c47c59c7123ea13c18cae2022-12-21T17:25:46ZengElsevierToxicology Reports2214-75002020-01-017155161Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio modelTamanna Kabir0Saeed Anwar1Jarin Taslem Mourosi2Jakir Hossain3Md. Golam Rabbane4Md. Masuder Rahman5Tohura Tahsin6Md. Nazmul Hasan7Manik Chandra Shill8Mohammad Jakir Hosen9Department of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, 3114, BangladeshDepartment of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, 3114, BangladeshDepartment of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, 3114, BangladeshDepartment of Fisheries, Faculty of Biological Sciences, University of Dhaka, Dhaka, 1200, Bangladesh; Department of Marine Fisheries and Oceanography, Faculty of Fisheries and Aquaculture, Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka 1207, BangladeshDepartment of Fisheries, Faculty of Biological Sciences, University of Dhaka, Dhaka, 1200, BangladeshDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, BangladeshDepartment of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, 3114, BangladeshDepartment of Genetic Engineering and Biotechnology, Jessore University of Science and Technology, Jessore, BangladeshDepartment of Pharmaceutical Sciences, North South University, Dhaka, BangladeshDepartment of Genetic Engineering & Biotechnology, School of Life Sciences, Shahjalal University of Science & Technology, Sylhet, 3114, Bangladesh; Corresponding author at: Department of Genetic Engineering & Biotechnology, Shahjalal University of Science & Technology, Sylhet, 3114, Bangladesh.Zebrafish (Danio rerio) has appeared as a valuable and popular model species to study the developmental and toxicological impact of environmental pollutants. To get insights on the toxicological effect of arsenic on early embryonic development, a controlled breeding of local Bangladeshi zebrafish followed by comprehensive microscopic analysis was conducted to study the embryonic development after exposure to different concentrations of arsenic ranges from 4−120 h post-fertilization. Zebrafish embryos exposed to 2 mM of arsenic displayed distinguishable developmental delay compared to control. At three days post-fertilization, a distinct phenotype appears in arsenic-treated embryos, which can be characterized by dechorionated embryos, larger egg mass, pericardial edema, abnormal heart rate, and abnormal head development. Remarkably, the death rate of the arsenic-treated embryos was significantly higher compared to control. Collectively, these findings indicate that exposure to arsenic may result in abnormal embryonic development. These results suggest for proper management of the pregnant mother in the arsenic-exposed area, and may also explain the incidence of increased miscarriage/abortion rate in arsenic water drinking pregnant mother.http://www.sciencedirect.com/science/article/pii/S2214750019301647Zebrafish modelArsenicEmbryonic developmentHeavy metalsToxicology |
| spellingShingle | Tamanna Kabir Saeed Anwar Jarin Taslem Mourosi Jakir Hossain Md. Golam Rabbane Md. Masuder Rahman Tohura Tahsin Md. Nazmul Hasan Manik Chandra Shill Mohammad Jakir Hosen Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model Toxicology Reports Zebrafish model Arsenic Embryonic development Heavy metals Toxicology |
| title | Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model |
| title_full | Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model |
| title_fullStr | Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model |
| title_full_unstemmed | Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model |
| title_short | Arsenic hampered embryonic development: An in vivo study using local Bangladeshi Danio rerio model |
| title_sort | arsenic hampered embryonic development an in vivo study using local bangladeshi danio rerio model |
| topic | Zebrafish model Arsenic Embryonic development Heavy metals Toxicology |
| url | http://www.sciencedirect.com/science/article/pii/S2214750019301647 |
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