Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles
In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addit...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2019-06-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461 |
| _version_ | 1818642134235873280 |
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| author | Ghaidan et al. |
| author_facet | Ghaidan et al. |
| author_sort | Ghaidan et al. |
| collection | DOAJ |
| description | In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively.
The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa. Also, a congestion of alveolar capillary was marked indicating pulmonary emphysema. The infiltration of alveolar macrophages showed the engulfed foreign particles (pad particles) within their cytoplasm, and peribronchial fibrosis. Group (B) showed the presence of pad particles (anthracosis), whereas the bronchial tree showed bronchitis with the bronchus-hyperplasia of mucin-producing cells (epithelial hyperplasia). Still another section showed an infiltration of mononuclear leukocytes and focal lobar necrosis. The third group (C), in turn, revealed acute interstitial bronchopneumonia with peribronchial focal necrosis and mild pulmonary edema with alveolar anthracosis.
As regards the liver, group (A) showed mild central venous congestion. Group (B), on the other hand, gave acute hepatitis, congestion of the central vein hyaline degeneration and mitotic figure having 2-3 nuclei. Severe congestion of the central vein with vascular amyloid deposition and most of the hepatocytes revealed coagulate necrosis in group (C). These changing tissues increased with increasing the exposure periods and were clearer in group (C) which was exposed for 12 weeks.
The continuous exposure to brake pad particles lead to damaging important body organs tissues and effect on human health, these particles can be considered as a type of pollutants added to air pollutants in different cities of Iraq. |
| first_indexed | 2024-12-16T23:38:14Z |
| format | Article |
| id | doaj.art-e39e02af3b8348f48445f3c4f6c68aed |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-16T23:38:14Z |
| publishDate | 2019-06-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-e39e02af3b8348f48445f3c4f6c68aed2022-12-21T22:11:42ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862019-06-0116210.21123/bsj.16.2.0306Histological Changes in the Lung and Liver of Mice Treated with Brake Pad ParticlesGhaidan et al.In the present study, the effects of brake pad particles of lung and liver histological sections were evaluated for (60) adult male mice. The animals were divided into three groups ( A,B,C) according to the periods of exposure (4, 8, and 12) weeks respectively exposed to brake pad particles in addition to the control groups (F) exposed to fresh air only. A special inhalation chamber designed locally has been used to expose the animals. The exposure to brake pad particles was (2.228) µg/m³ for 30 min/day, 5 days/week for (4,8and12) weeks respectively. The examination in group (A) of the histological sections of the lung showed the thickness of interalveolar septa. Also, a congestion of alveolar capillary was marked indicating pulmonary emphysema. The infiltration of alveolar macrophages showed the engulfed foreign particles (pad particles) within their cytoplasm, and peribronchial fibrosis. Group (B) showed the presence of pad particles (anthracosis), whereas the bronchial tree showed bronchitis with the bronchus-hyperplasia of mucin-producing cells (epithelial hyperplasia). Still another section showed an infiltration of mononuclear leukocytes and focal lobar necrosis. The third group (C), in turn, revealed acute interstitial bronchopneumonia with peribronchial focal necrosis and mild pulmonary edema with alveolar anthracosis. As regards the liver, group (A) showed mild central venous congestion. Group (B), on the other hand, gave acute hepatitis, congestion of the central vein hyaline degeneration and mitotic figure having 2-3 nuclei. Severe congestion of the central vein with vascular amyloid deposition and most of the hepatocytes revealed coagulate necrosis in group (C). These changing tissues increased with increasing the exposure periods and were clearer in group (C) which was exposed for 12 weeks. The continuous exposure to brake pad particles lead to damaging important body organs tissues and effect on human health, these particles can be considered as a type of pollutants added to air pollutants in different cities of Iraq.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission. |
| spellingShingle | Ghaidan et al. Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles Baghdad Science Journal Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission. |
| title | Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles |
| title_full | Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles |
| title_fullStr | Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles |
| title_full_unstemmed | Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles |
| title_short | Histological Changes in the Lung and Liver of Mice Treated with Brake Pad Particles |
| title_sort | histological changes in the lung and liver of mice treated with brake pad particles |
| topic | Brake pad particles, Heavy metals, Liver, Lung, Non-exhaust emission. |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3461 |
| work_keys_str_mv | AT ghaidanetal histologicalchangesinthelungandliverofmicetreatedwithbrakepadparticles |