Quercetin Hybrids—Synthesis, Spectral Characterization and Radical Scavenging Potential

Quercetin Hybrids—Synthesis, Spectral Characterization and Radical Scavenging Potential

New quercetin-based derivatives are synthesized in an easily accessible one-pot manner. The method is based on the reaction of quercetin with in situ formed electrophilic <i>N</i>-alkoxycarbonylazolium ions. The position of the newly formed C-C bond and structure were spectrally characte...

Full description

Bibliographic Details
Main Authors: Desislava Kirkova, Yordan Stremski, Stela Statkova-Abeghe, Margarita Docheva
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molbank
Subjects:
quercetin
benzazoles
<i>N</i>-acyliminium ions
one-pot reaction
antioxidant activity
Online Access:https://www.mdpi.com/1422-8599/2022/1/M1329
Description
Summary:New quercetin-based derivatives are synthesized in an easily accessible one-pot manner. The method is based on the reaction of quercetin with in situ formed electrophilic <i>N</i>-alkoxycarbonylazolium ions. The position of the newly formed C-C bond and structure were spectrally characterized by 1D, 2D <sup>1</sup>H, <sup>13</sup>C-NMR, IR, and MS analysis. Thus, in all cases, good regioselectivity in the C-8 position for the obtained products was demonstrated. The obtained compounds were evaluated for their DPPH and ABTS free radical scavenging activity and compared to natural compounds—quercetin and rutin.
ISSN:1422-8599

Similar Items