The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification
Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to comorbidities. During these age-related diseases, the e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.854726/full |
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| author | Cristina Mas-Bargues Cristina Mas-Bargues Cristina Mas-Bargues Consuelo Borrás Consuelo Borrás Consuelo Borrás Matilde Alique Matilde Alique |
| author_facet | Cristina Mas-Bargues Cristina Mas-Bargues Cristina Mas-Bargues Consuelo Borrás Consuelo Borrás Consuelo Borrás Matilde Alique Matilde Alique |
| author_sort | Cristina Mas-Bargues |
| collection | DOAJ |
| description | Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to comorbidities. During these age-related diseases, the endothelium accumulates senescent cells, which stimulate calcification in vascular smooth muscle cells. Currently, vascular calcification is a silent pathology, and there are no early diagnostic tools. Therefore, by the time vascular calcification is diagnosed, it is usually untreatable. Some mediators, such as oxidative stress, inflammation, and extracellular vesicles, are inducers and promoters of vascular calcification. They play a crucial role during vascular generation and the progression of vascular calcification. Extracellular vesicles, mainly derived from injured endothelial cells that have acquired a senescent phenotype, contribute to calcification in a manner mostly dependent on two factors: (1) the number of extracellular vesicles released, and (2) their cargo. In this review, we present state-of-the-art knowledge on the composition and functions of extracellular vesicles involved in the generation and progression of vascular calcification. |
| first_indexed | 2024-12-12T19:43:28Z |
| format | Article |
| id | doaj.art-e39f21f66f334e59a604a2739b90a477 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-12T19:43:28Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e39f21f66f334e59a604a2739b90a4772022-12-22T00:14:09ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.854726854726The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular CalcificationCristina Mas-Bargues0Cristina Mas-Bargues1Cristina Mas-Bargues2Consuelo Borrás3Consuelo Borrás4Consuelo Borrás5Matilde Alique6Matilde Alique7Grupo de Investigación Freshage, Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, SpainInstituto Sanitario de Investigación INCLIVA, Valencia, SpainCentro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III (CIBERFES, ISCIII), Madrid, SpainGrupo de Investigación Freshage, Departamento de Fisiología, Facultad de Medicina, Universidad de Valencia, Valencia, SpainInstituto Sanitario de Investigación INCLIVA, Valencia, SpainCentro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III (CIBERFES, ISCIII), Madrid, SpainDepartamento de Biología de Sistemas, Universidad de Alcalá, Madrid, SpainInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, SpainVascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to comorbidities. During these age-related diseases, the endothelium accumulates senescent cells, which stimulate calcification in vascular smooth muscle cells. Currently, vascular calcification is a silent pathology, and there are no early diagnostic tools. Therefore, by the time vascular calcification is diagnosed, it is usually untreatable. Some mediators, such as oxidative stress, inflammation, and extracellular vesicles, are inducers and promoters of vascular calcification. They play a crucial role during vascular generation and the progression of vascular calcification. Extracellular vesicles, mainly derived from injured endothelial cells that have acquired a senescent phenotype, contribute to calcification in a manner mostly dependent on two factors: (1) the number of extracellular vesicles released, and (2) their cargo. In this review, we present state-of-the-art knowledge on the composition and functions of extracellular vesicles involved in the generation and progression of vascular calcification.https://www.frontiersin.org/articles/10.3389/fcvm.2022.854726/fullagingaging-related diseasesextracellular vesiclesinflammationmedial arterial calcificationsenescence |
| spellingShingle | Cristina Mas-Bargues Cristina Mas-Bargues Cristina Mas-Bargues Consuelo Borrás Consuelo Borrás Consuelo Borrás Matilde Alique Matilde Alique The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification Frontiers in Cardiovascular Medicine aging aging-related diseases extracellular vesicles inflammation medial arterial calcification senescence |
| title | The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification |
| title_full | The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification |
| title_fullStr | The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification |
| title_full_unstemmed | The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification |
| title_short | The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification |
| title_sort | contribution of extracellular vesicles from senescent endothelial and vascular smooth muscle cells to vascular calcification |
| topic | aging aging-related diseases extracellular vesicles inflammation medial arterial calcification senescence |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.854726/full |
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