Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans
Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin dom...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18440-6 |
| _version_ | 1830207173960925184 |
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| author | Daniel L. Hurdiss Ieva Drulyte Yifei Lang Tatiana M. Shamorkina Matti F. Pronker Frank J. M. van Kuppeveld Joost Snijder Raoul J. de Groot |
| author_facet | Daniel L. Hurdiss Ieva Drulyte Yifei Lang Tatiana M. Shamorkina Matti F. Pronker Frank J. M. van Kuppeveld Joost Snijder Raoul J. de Groot |
| author_sort | Daniel L. Hurdiss |
| collection | DOAJ |
| description | Human coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin domain covered with a putative glycan shield; and they discuss these features in the context of host adaptation. |
| first_indexed | 2024-12-18T04:26:35Z |
| format | Article |
| id | doaj.art-e39f8123487b43869c78601f60414a16 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:26:35Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e39f8123487b43869c78601f60414a162022-12-21T21:21:06ZengNature PortfolioNature Communications2041-17232020-09-0111111010.1038/s41467-020-18440-6Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humansDaniel L. Hurdiss0Ieva Drulyte1Yifei Lang2Tatiana M. Shamorkina3Matti F. Pronker4Frank J. M. van Kuppeveld5Joost Snijder6Raoul J. de Groot7Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityMaterials and Structural Analysis, Thermo Fisher ScientificVirology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityVirology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityVirology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityHuman coronavirus-HKU1 contains two surface projections called spike and haemagglutinin-esterase (HE), with the latter acting as a receptor-destroying enzyme. Here, the authors use cryo-EM and mass spectrometry to characterise the small, heavily glycosylated HKU1 HE, revealing a vestigial lectin domain covered with a putative glycan shield; and they discuss these features in the context of host adaptation.https://doi.org/10.1038/s41467-020-18440-6 |
| spellingShingle | Daniel L. Hurdiss Ieva Drulyte Yifei Lang Tatiana M. Shamorkina Matti F. Pronker Frank J. M. van Kuppeveld Joost Snijder Raoul J. de Groot Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans Nature Communications |
| title | Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| title_full | Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| title_fullStr | Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| title_full_unstemmed | Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| title_short | Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| title_sort | cryo em structure of coronavirus hku1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans |
| url | https://doi.org/10.1038/s41467-020-18440-6 |
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