An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive
Auditory brainstem neurons in the lateral superior olive (LSO) receive excitatory input from the ipsilateral cochlear nucleus (CN) and inhibitory transmission from the contralateral CN via the medial nucleus of the trapezoid body (MNTB). This circuit enables sound localization using interaural level...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncir.2023.1307283/full |
| _version_ | 1797434939861368832 |
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| author | Dennis J. Weingarten Eva Sebastian Jennifer Winkelhoff Jennifer Winkelhoff Nadine Patschull-Keiner Alexander U. Fischer Simon L. Wadle Eckhard Friauf Jan J. Hirtz |
| author_facet | Dennis J. Weingarten Eva Sebastian Jennifer Winkelhoff Jennifer Winkelhoff Nadine Patschull-Keiner Alexander U. Fischer Simon L. Wadle Eckhard Friauf Jan J. Hirtz |
| author_sort | Dennis J. Weingarten |
| collection | DOAJ |
| description | Auditory brainstem neurons in the lateral superior olive (LSO) receive excitatory input from the ipsilateral cochlear nucleus (CN) and inhibitory transmission from the contralateral CN via the medial nucleus of the trapezoid body (MNTB). This circuit enables sound localization using interaural level differences. Early studies have observed an additional inhibitory input originating from the ipsilateral side. However, many of its details, such as its origin, remained elusive. Employing electrical and optical stimulation of afferents in acute mouse brainstem slices and anatomical tracing, we here describe a glycinergic projection to LSO principal neurons that originates from the ipsilateral CN. This inhibitory synaptic input likely mediates inhibitory sidebands of LSO neurons in response to acoustic stimulation. |
| first_indexed | 2024-03-09T10:40:07Z |
| format | Article |
| id | doaj.art-e3a11fe4fb1a44fbb5271f847461df14 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-03-09T10:40:07Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-e3a11fe4fb1a44fbb5271f847461df142023-12-01T16:22:19ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102023-12-011710.3389/fncir.2023.13072831307283An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior oliveDennis J. Weingarten0Eva Sebastian1Jennifer Winkelhoff2Jennifer Winkelhoff3Nadine Patschull-Keiner4Alexander U. Fischer5Simon L. Wadle6Eckhard Friauf7Jan J. Hirtz8Animal Physiology Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyPhysiology of Neuronal Networks Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyAnimal Physiology Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyPhysiology of Neuronal Networks Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyAnimal Physiology Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyAnimal Physiology Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyPhysiology of Neuronal Networks Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyAnimal Physiology Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyPhysiology of Neuronal Networks Group, Department of Biology, RPTU University of Kaiserslautern-Landau, Kaiserslautern, GermanyAuditory brainstem neurons in the lateral superior olive (LSO) receive excitatory input from the ipsilateral cochlear nucleus (CN) and inhibitory transmission from the contralateral CN via the medial nucleus of the trapezoid body (MNTB). This circuit enables sound localization using interaural level differences. Early studies have observed an additional inhibitory input originating from the ipsilateral side. However, many of its details, such as its origin, remained elusive. Employing electrical and optical stimulation of afferents in acute mouse brainstem slices and anatomical tracing, we here describe a glycinergic projection to LSO principal neurons that originates from the ipsilateral CN. This inhibitory synaptic input likely mediates inhibitory sidebands of LSO neurons in response to acoustic stimulation.https://www.frontiersin.org/articles/10.3389/fncir.2023.1307283/fullmousehearingsuperior olivary complexpatch-clampoptogenetics |
| spellingShingle | Dennis J. Weingarten Eva Sebastian Jennifer Winkelhoff Jennifer Winkelhoff Nadine Patschull-Keiner Alexander U. Fischer Simon L. Wadle Eckhard Friauf Jan J. Hirtz An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive Frontiers in Neural Circuits mouse hearing superior olivary complex patch-clamp optogenetics |
| title | An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| title_full | An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| title_fullStr | An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| title_full_unstemmed | An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| title_short | An inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| title_sort | inhibitory glycinergic projection from the cochlear nucleus to the lateral superior olive |
| topic | mouse hearing superior olivary complex patch-clamp optogenetics |
| url | https://www.frontiersin.org/articles/10.3389/fncir.2023.1307283/full |
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