Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial
Abstract Background Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calciton...
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-022-00802-z |
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| author | Maedeh Babapour Fariborz Khorvash Mohammad Hossein Rouhani Abed Ghavami Hatav Ghasemi‐Tehrani Zahra Heidari Mojtaba Karbasi Fatemeh Moradi Gholamreza Askari |
| author_facet | Maedeh Babapour Fariborz Khorvash Mohammad Hossein Rouhani Abed Ghavami Hatav Ghasemi‐Tehrani Zahra Heidari Mojtaba Karbasi Fatemeh Moradi Gholamreza Askari |
| author_sort | Maedeh Babapour |
| collection | DOAJ |
| description | Abstract Background Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calcitonin gene-related peptide (CGRP) levels in women with migraine. Methods Eighty-three participants completed a randomized double-blind controlled trial, receiving 50 mg per day soy isoflavones or placebo supplementation for 8 weeks. Migraine severity, migraine days per month, frequency and duration of attacks, mental status, quality of life and serum CGRP levels were measured at baseline and the end of the intervention. Bivariate comparison and intention-to-treat (ITT) were used for analysis. Results Soy isoflavones intake resulted in a significant decrease in mean frequency (-2.36 vs -0.43, P < 0.001), duration (-2.50 vs -0.02, P < 0.001) of migraine attacks and CGRP level (-12.18 ng/l vs -8.62, P = 0.002) in compared to placebo group. Also, a significant improvement was found in quality of life (16.76 vs 2.52, P < 0.001). Although, reduction in the migraine severity and mental status did not reach a statistically significant level (P > 0.05). Conclusion soy isoflavones supplementation may be considered as a complementary treatment for women with migraine to improve migraine characteristics and reduce the burden of disease. |
| first_indexed | 2024-04-14T07:33:25Z |
| format | Article |
| id | doaj.art-e3a1595466254a7cb636a99ec5e5edcc |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-04-14T07:33:25Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-e3a1595466254a7cb636a99ec5e5edcc2022-12-22T02:05:48ZengBMCNutrition Journal1475-28912022-07-0121111110.1186/s12937-022-00802-zEffect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trialMaedeh Babapour0Fariborz Khorvash1Mohammad Hossein Rouhani2Abed Ghavami3Hatav Ghasemi‐Tehrani4Zahra Heidari5Mojtaba Karbasi6Fatemeh Moradi7Gholamreza Askari8Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesNeurology Research Center, School of Medicine, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Reproductive, Shahid Beheshti Fertility and Infertility Clinic, Isfahan University of Medical SciencesDepartment of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical SciencesDepartment of English Language, Faculty of Information and Medical Informatics, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesDepartment of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical SciencesAbstract Background Literature suggests a relationship between estrogen levels and migraine headache pathogenesis. However, the effect of soy isoflavones on migraine characteristic remains unclear. This study aimed to investigate the effect of soy isoflavones on migraine characteristics and calcitonin gene-related peptide (CGRP) levels in women with migraine. Methods Eighty-three participants completed a randomized double-blind controlled trial, receiving 50 mg per day soy isoflavones or placebo supplementation for 8 weeks. Migraine severity, migraine days per month, frequency and duration of attacks, mental status, quality of life and serum CGRP levels were measured at baseline and the end of the intervention. Bivariate comparison and intention-to-treat (ITT) were used for analysis. Results Soy isoflavones intake resulted in a significant decrease in mean frequency (-2.36 vs -0.43, P < 0.001), duration (-2.50 vs -0.02, P < 0.001) of migraine attacks and CGRP level (-12.18 ng/l vs -8.62, P = 0.002) in compared to placebo group. Also, a significant improvement was found in quality of life (16.76 vs 2.52, P < 0.001). Although, reduction in the migraine severity and mental status did not reach a statistically significant level (P > 0.05). Conclusion soy isoflavones supplementation may be considered as a complementary treatment for women with migraine to improve migraine characteristics and reduce the burden of disease.https://doi.org/10.1186/s12937-022-00802-zMigraineHeadacheSoy IsoflavonesCGRP |
| spellingShingle | Maedeh Babapour Fariborz Khorvash Mohammad Hossein Rouhani Abed Ghavami Hatav Ghasemi‐Tehrani Zahra Heidari Mojtaba Karbasi Fatemeh Moradi Gholamreza Askari Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial Nutrition Journal Migraine Headache Soy Isoflavones CGRP |
| title | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| title_full | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| title_fullStr | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| title_full_unstemmed | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| title_short | Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial |
| title_sort | effect of soy isoflavones supplementation on migraine characteristics mental status and calcitonin gene related peptide cgrp levels in women with migraine results of randomised controlled trial |
| topic | Migraine Headache Soy Isoflavones CGRP |
| url | https://doi.org/10.1186/s12937-022-00802-z |
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