Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine
The foot and mouth disease (FMD) vaccine is used to control the FMD in cloven-hoofed animals including calves. The most important step in vaccine preparation is the selection of a suitable adjuvant which plays a main role in the vaccine’s potency. The present study is an attempt to use clinoptilolit...
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| Format: | Article |
| Language: | Arabic |
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The Union of Arab Universities
2021-12-01
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| Series: | Arab Universities Journal of Agricultural Sciences |
| Subjects: | |
| Online Access: | https://ajs.journals.ekb.eg/article_211687_a80f9ba8e77bb96e89db4adc6f92f4dd.pdf |
| _version_ | 1797269906196004864 |
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| author | Nour Elhoda Tamim Dawlat Salama Hani Srour Ehab Ibrahim |
| author_facet | Nour Elhoda Tamim Dawlat Salama Hani Srour Ehab Ibrahim |
| author_sort | Nour Elhoda Tamim |
| collection | DOAJ |
| description | The foot and mouth disease (FMD) vaccine is used to control the FMD in cloven-hoofed animals including calves. The most important step in vaccine preparation is the selection of a suitable adjuvant which plays a main role in the vaccine’s potency. The present study is an attempt to use clinoptilolite instead of Montanide oil to enhance the efficiency of the FMD vaccine and reduce its production cost. Twelve calves were split into four groups. Three groups were vaccinated with FMD vaccine with different adjuvants i.e. 100% Montanide (ISA 206), 50% of Montanide with 1.0 μg/dose of clinoptilolite (ISA 206+CLINP), and by replacing the 100% of Montanide to 1μg/dose of clinoptilolite (CLINP). The fourth group was unvaccinated. Results showed that calves vaccinated with (ISA 206+CLINP) FMD vaccine expressed the highest and the longest periods of immune response until 38 weeks. While groups vaccinated with (CLINP) or (ISA 206) vaccine showed only protection up to 26 and 34 weeks respectively. Also, our results showed that clinoptilolite improved organ functions resulting from the stress of vaccines. Finally, this study recommended the use of clinoptilolite with Montanide oil as a potential adjuvant in the FMD vaccine to give high stimulation of the immune response. |
| first_indexed | 2024-04-25T01:55:49Z |
| format | Article |
| id | doaj.art-e3a285d69162420da9197fe4ef6b10a4 |
| institution | Directory Open Access Journal |
| issn | 1110-2675 2636-3585 |
| language | Arabic |
| last_indexed | 2024-04-25T01:55:49Z |
| publishDate | 2021-12-01 |
| publisher | The Union of Arab Universities |
| record_format | Article |
| series | Arab Universities Journal of Agricultural Sciences |
| spelling | doaj.art-e3a285d69162420da9197fe4ef6b10a42024-03-07T17:27:41ZaraThe Union of Arab UniversitiesArab Universities Journal of Agricultural Sciences1110-26752636-35852021-12-0129382383210.21608/ajs.2021.87950.1403211687Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease VaccineNour Elhoda Tamim0Dawlat Salama1Hani Srour2Ehab Ibrahim3Foot and Mouth Diseases Department, Veterinary Serum and Vaccine Research Institute, Abbasia, Agriculture research center (ARC), Cairo, EgyptAgricultural Biochemistry Department, Faculty of Agriculture, Ain shams University, Cairo, EgyptAgricultural Biochemistry Department, Faculty of Agriculture, Ain Shams University, Cairo, Egypt.Foot and Mouth Diseases Department, Veterinary Serum and Vaccine Research Institute, Abbasia, Agriculture research center (ARC), Cairo, EgyptThe foot and mouth disease (FMD) vaccine is used to control the FMD in cloven-hoofed animals including calves. The most important step in vaccine preparation is the selection of a suitable adjuvant which plays a main role in the vaccine’s potency. The present study is an attempt to use clinoptilolite instead of Montanide oil to enhance the efficiency of the FMD vaccine and reduce its production cost. Twelve calves were split into four groups. Three groups were vaccinated with FMD vaccine with different adjuvants i.e. 100% Montanide (ISA 206), 50% of Montanide with 1.0 μg/dose of clinoptilolite (ISA 206+CLINP), and by replacing the 100% of Montanide to 1μg/dose of clinoptilolite (CLINP). The fourth group was unvaccinated. Results showed that calves vaccinated with (ISA 206+CLINP) FMD vaccine expressed the highest and the longest periods of immune response until 38 weeks. While groups vaccinated with (CLINP) or (ISA 206) vaccine showed only protection up to 26 and 34 weeks respectively. Also, our results showed that clinoptilolite improved organ functions resulting from the stress of vaccines. Finally, this study recommended the use of clinoptilolite with Montanide oil as a potential adjuvant in the FMD vaccine to give high stimulation of the immune response.https://ajs.journals.ekb.eg/article_211687_a80f9ba8e77bb96e89db4adc6f92f4dd.pdfadjuvantbiochemical parameterscalvesfmdhumoral immunityvaccine |
| spellingShingle | Nour Elhoda Tamim Dawlat Salama Hani Srour Ehab Ibrahim Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine Arab Universities Journal of Agricultural Sciences adjuvant biochemical parameters calves fmd humoral immunity vaccine |
| title | Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine |
| title_full | Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine |
| title_fullStr | Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine |
| title_full_unstemmed | Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine |
| title_short | Effect of Clinoptilolite on Humoral Immunity and Biochemical Parameters in Calves Vaccinated with Foot and Mouth Disease Vaccine |
| title_sort | effect of clinoptilolite on humoral immunity and biochemical parameters in calves vaccinated with foot and mouth disease vaccine |
| topic | adjuvant biochemical parameters calves fmd humoral immunity vaccine |
| url | https://ajs.journals.ekb.eg/article_211687_a80f9ba8e77bb96e89db4adc6f92f4dd.pdf |
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