Bone Marrow Stroma-Induced Transcriptome and Regulome Signatures of Multiple Myeloma

Bone Marrow Stroma-Induced Transcriptome and Regulome Signatures of Multiple Myeloma

Multiple myeloma (MM) is a hematological cancer with inevitable drug resistance. MM cells interacting with bone marrow stromal cells (BMSCs) undergo substantial changes in the transcriptome and develop de novo multi-drug resistance. As a critical component in transcriptional regulation, how the chro...

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Bibliographic Details
Main Authors: Sebastian A. Dziadowicz, Lei Wang, Halima Akhter, Drake Aesoph, Tulika Sharma, Donald A. Adjeroh, Lori A. Hazlehurst, Gangqing Hu
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
multiple myeloma
bone marrow stromal cells
de novo drug resistance
transcriptome
regulome
epigenetic regulation
Online Access:https://www.mdpi.com/2072-6694/14/4/927

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