Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders
Deficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for an association between neural value signals and symptoms of amotiva...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222002923 |
| _version_ | 1797995896848252928 |
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| author | Min K. Souther Daniel H. Wolf Rebecca Kazinka Sangil Lee Kosha Ruparel Mark A. Elliott Anna Xu Matthew Cieslak Greer Prettyman Theodore D. Satterthwaite Joseph W. Kable |
| author_facet | Min K. Souther Daniel H. Wolf Rebecca Kazinka Sangil Lee Kosha Ruparel Mark A. Elliott Anna Xu Matthew Cieslak Greer Prettyman Theodore D. Satterthwaite Joseph W. Kable |
| author_sort | Min K. Souther |
| collection | DOAJ |
| description | Deficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for an association between neural value signals and symptoms of amotivation and anhedonia across adults with major depression, bipolar disorder, schizophrenia, or no psychiatric diagnosis. We found that value signals in the ventromedial prefrontal cortex (vmPFC) during intertemporal decision-making were dampened in individuals with greater motivational and hedonic deficits, after accounting for primary diagnosis. This relationship remained significant while controlling for diagnosis-specific symptoms of mood and psychosis, such as depression as well as positive and negative symptoms. Our results demonstrate that dysfunction in the vmPFC during value-based decision-making is specifically linked to motivational and hedonic impairments. These findings provide a quantitative neural target for the potential development of novel treatments for amotivation and anhedonia. |
| first_indexed | 2024-04-11T10:08:55Z |
| format | Article |
| id | doaj.art-e3a3326fccb3418a9b4633a58dec274e |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-11T10:08:55Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-e3a3326fccb3418a9b4633a58dec274e2022-12-22T04:30:10ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103227Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disordersMin K. Souther0Daniel H. Wolf1Rebecca Kazinka2Sangil Lee3Kosha Ruparel4Mark A. Elliott5Anna Xu6Matthew Cieslak7Greer Prettyman8Theodore D. Satterthwaite9Joseph W. Kable10Department of Psychology, University of Pennsylvania, US; Corresponding author at: Department of Psychology, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, PA 19104, USDepartment of Psychiatry, Perelman School of Medicine, USDepartment of Psychology, University of Pennsylvania, US; Department of Psychiatry, University of Minnesota, USDepartment of Psychology, University of Pennsylvania, USDepartment of Psychiatry, Perelman School of Medicine, USDepartment of Radiology, University of Pennsylvania, USDepartment of Psychiatry, Perelman School of Medicine, USDepartment of Psychiatry, Perelman School of Medicine, USDepartment of Psychiatry, Perelman School of Medicine, USDepartment of Psychiatry, Perelman School of Medicine, US; Penn-CHOP Lifespan Brain Institute, USDepartment of Psychology, University of Pennsylvania, USDeficits in motivation and pleasure are common across many psychiatric disorders, and manifest as symptoms of amotivation and anhedonia, which are prominent features of both mood and psychotic disorders. Here we provide evidence for an association between neural value signals and symptoms of amotivation and anhedonia across adults with major depression, bipolar disorder, schizophrenia, or no psychiatric diagnosis. We found that value signals in the ventromedial prefrontal cortex (vmPFC) during intertemporal decision-making were dampened in individuals with greater motivational and hedonic deficits, after accounting for primary diagnosis. This relationship remained significant while controlling for diagnosis-specific symptoms of mood and psychosis, such as depression as well as positive and negative symptoms. Our results demonstrate that dysfunction in the vmPFC during value-based decision-making is specifically linked to motivational and hedonic impairments. These findings provide a quantitative neural target for the potential development of novel treatments for amotivation and anhedonia.http://www.sciencedirect.com/science/article/pii/S2213158222002923AnhedoniaDepressionBipolar disorderSchizophreniaVentromedial prefrontal cortexfMRI |
| spellingShingle | Min K. Souther Daniel H. Wolf Rebecca Kazinka Sangil Lee Kosha Ruparel Mark A. Elliott Anna Xu Matthew Cieslak Greer Prettyman Theodore D. Satterthwaite Joseph W. Kable Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders NeuroImage: Clinical Anhedonia Depression Bipolar disorder Schizophrenia Ventromedial prefrontal cortex fMRI |
| title | Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| title_full | Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| title_fullStr | Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| title_full_unstemmed | Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| title_short | Decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| title_sort | decision value signals in the ventromedial prefrontal cortex and motivational and hedonic symptoms across mood and psychotic disorders |
| topic | Anhedonia Depression Bipolar disorder Schizophrenia Ventromedial prefrontal cortex fMRI |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222002923 |
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