The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies
Abstract: In contrast to traditional reviews, systematic reviews explore theliterature on a specific topic comprehensively using a well-defined protocol and recruit the findings of eligible studies after the assessment of their qualities, using a clear and reproducible method. Checking the assumptio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2007-12-01
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| Series: | Iranian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/453 |
| _version_ | 1818980861789339648 |
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| author | Behzad Hajarizadeh Behnam Sadeghirad Ali-Akbar Haghdoost Ali Mirzazadeh |
| author_facet | Behzad Hajarizadeh Behnam Sadeghirad Ali-Akbar Haghdoost Ali Mirzazadeh |
| author_sort | Behzad Hajarizadeh |
| collection | DOAJ |
| description | Abstract: In contrast to traditional reviews, systematic reviews explore theliterature on a specific topic comprehensively using a well-defined protocol and recruit the findings of eligible studies after the assessment of their qualities, using a clear and reproducible method. Checking the assumptions, we may merge the findings of recruited studies in a systematic review and use metaanalysis techniques not only to estimate the pooled effect but also to assess the possible sources of heterogeneity and the extend of heterogeneity in the findings . Generally, randomized clinical trials are the most common type of studies which are recruiting in systematic reviews and meta-analyses. However, we couldn't ignore the importance of observational studies particularly in sensitivity topics with ethical limitations against interventional studies. Although we are usually faced with wide variations in the methodology of observational studies even in narrow topics, systematic review and meta-analysis of their results can generatevaluable findings. They are particularly useful for explaining the source of heterogeneity in the results of primary observational studies .In this paper, we review the basic concepts of the systematic review and metaanalysis and their main applications in summarizing the findings of observational studies with respect to their advantages and limitations. |
| first_indexed | 2024-12-20T17:22:09Z |
| format | Article |
| id | doaj.art-e3a3b09d788e49799bb79f3057247820 |
| institution | Directory Open Access Journal |
| issn | 1735-4587 2008-2215 |
| language | English |
| last_indexed | 2024-12-20T17:22:09Z |
| publishDate | 2007-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj.art-e3a3b09d788e49799bb79f30572478202022-12-21T19:31:44ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152007-12-0124The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational StudiesBehzad Hajarizadeh0Behnam Sadeghirad1Ali-Akbar Haghdoost2Ali Mirzazadeh3UNAIDS country office, Tehran, IranNeuroscience Research Centre, University of Medical Sciences, Kerman, IranDepartment of Epidemiology, Kerman University of Medical Sciences, Physiology Research Centre, Kerman, Iran London School of Hygiene and Tropical Medicine, London, UKKerman University of Medical Sciences, Physiology Research Centre, Kerman, IranAbstract: In contrast to traditional reviews, systematic reviews explore theliterature on a specific topic comprehensively using a well-defined protocol and recruit the findings of eligible studies after the assessment of their qualities, using a clear and reproducible method. Checking the assumptions, we may merge the findings of recruited studies in a systematic review and use metaanalysis techniques not only to estimate the pooled effect but also to assess the possible sources of heterogeneity and the extend of heterogeneity in the findings . Generally, randomized clinical trials are the most common type of studies which are recruiting in systematic reviews and meta-analyses. However, we couldn't ignore the importance of observational studies particularly in sensitivity topics with ethical limitations against interventional studies. Although we are usually faced with wide variations in the methodology of observational studies even in narrow topics, systematic review and meta-analysis of their results can generatevaluable findings. They are particularly useful for explaining the source of heterogeneity in the results of primary observational studies .In this paper, we review the basic concepts of the systematic review and metaanalysis and their main applications in summarizing the findings of observational studies with respect to their advantages and limitations.https://ijps.tums.ac.ir/index.php/ijps/article/view/453Epidemiologic studiesMental healthSystematic reviewMeta-analysis |
| spellingShingle | Behzad Hajarizadeh Behnam Sadeghirad Ali-Akbar Haghdoost Ali Mirzazadeh The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies Iranian Journal of Psychiatry Epidemiologic studies Mental health Systematic review Meta-analysis |
| title | The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies |
| title_full | The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies |
| title_fullStr | The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies |
| title_full_unstemmed | The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies |
| title_short | The Application of Systematic Review and Meta-analysis Concepts in Summarizing the Findings of Observational Studies |
| title_sort | application of systematic review and meta analysis concepts in summarizing the findings of observational studies |
| topic | Epidemiologic studies Mental health Systematic review Meta-analysis |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/453 |
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