Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019
Abstract Objective Adopting a healthy lifestyle, including regular physical activity, is widely believed to decrease cancer risk. This study aimed to quantitatively establish the dose‐response relationships between total physical activity and the risk of breast, colon, lung, gastric, and liver cance...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-11-01
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| Series: | Cancer Communications |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cac2.12488 |
| _version_ | 1797633679549267968 |
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| author | Xiayao Diao Yudong Ling Yi Zeng Yueqian Wu Chao Guo Yukai Jin Xiaojiang Chen Shoucheng Feng Jianrong Guo Chao Ding Feiyu Diao Zhicheng Du Shanqing Li Haibo Qiu |
| author_facet | Xiayao Diao Yudong Ling Yi Zeng Yueqian Wu Chao Guo Yukai Jin Xiaojiang Chen Shoucheng Feng Jianrong Guo Chao Ding Feiyu Diao Zhicheng Du Shanqing Li Haibo Qiu |
| author_sort | Xiayao Diao |
| collection | DOAJ |
| description | Abstract Objective Adopting a healthy lifestyle, including regular physical activity, is widely believed to decrease cancer risk. This study aimed to quantitatively establish the dose‐response relationships between total physical activity and the risk of breast, colon, lung, gastric, and liver cancers. Methods A systematic review and dose‐response analysis were conducted using PubMed and Embase from January 1, 1980 to March 20, 2023. Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included. The search was confined to publications in the English language with a specific focus on human studies. Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys (NHANES) and the Global Burden of Disease 2019 database. Results A total of 98 studies, involving a combined population of 16,418,361 individuals, were included in the analysis. Among the included studies, 57 focused on breast cancer, 17 on lung cancer, 23 on colon cancer, 5 on gastric cancer, and 7 on liver cancer. Overall, elevated levels of physical activity exhibited an inverse correlation with the risk of cancer. The dose‐response curve for lung cancer exhibited a non‐linear pattern, with the greatest benefit risk reduction observed at 13,200 MET‐minutes/week of physical activity, resulting in a 14.7% reduction in risk (relative risk 0.853, uncertainty interval 0.798 to 0.912) compared to the inactive population. In contrast, the dose‐response curves for colon, gastric, breast, and liver cancers showed linear associations, indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks. However, the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers. Compared to individuals with insufficient activity (total activity level < 600 MET‐minutes/week), individuals with high levels of activity (≥ 8,000 MET‐minutes/week) experienced a 10.3% (0.897, 0.860 to 0.934) risk reduction for breast cancer; 5.9% (0.941, 0.884 to 1.001) for lung cancer; 7.1% (0.929, 0.909 to 0.949) for colon cancer; 5.1% (0.949, 0.908 to 0.992) for gastric cancer; 17.1% (0.829, 0.760 to 0.903) for liver cancer. Conclusions This study demonstrated a significant inverse relationship between total physical activity and the risk of breast, gastric, liver, colon, and lung cancers. |
| first_indexed | 2024-03-11T11:57:17Z |
| format | Article |
| id | doaj.art-e3a3cf4708e040a18634a81bd52f64f1 |
| institution | Directory Open Access Journal |
| issn | 2523-3548 |
| language | English |
| last_indexed | 2024-03-11T11:57:17Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Communications |
| spelling | doaj.art-e3a3cf4708e040a18634a81bd52f64f12023-11-08T15:31:49ZengWileyCancer Communications2523-35482023-11-0143111229124310.1002/cac2.12488Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019Xiayao Diao0Yudong Ling1Yi Zeng2Yueqian Wu3Chao Guo4Yukai Jin5Xiaojiang Chen6Shoucheng Feng7Jianrong Guo8Chao Ding9Feiyu Diao10Zhicheng Du11Shanqing Li12Haibo Qiu13Department of Thoracic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Medical Statistics School of Public Health Sun Yat‐sen University Guangzhou Guangdong P. R. ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaDepartment of General Surgery Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou Guangdong P. R. ChinaDepartment of Medical Statistics School of Public Health Sun Yat‐sen University Guangzhou Guangdong P. R. ChinaDepartment of Thoracic Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. ChinaDepartment of Gastric Surgery Sun Yat‐sen University Cancer Center Guangzhou Guangdong P. R. ChinaAbstract Objective Adopting a healthy lifestyle, including regular physical activity, is widely believed to decrease cancer risk. This study aimed to quantitatively establish the dose‐response relationships between total physical activity and the risk of breast, colon, lung, gastric, and liver cancers. Methods A systematic review and dose‐response analysis were conducted using PubMed and Embase from January 1, 1980 to March 20, 2023. Prospective cohort studies that examined the association between physical activity and the risks of any of the 5 outcomes were included. The search was confined to publications in the English language with a specific focus on human studies. Physical activity is standardized by using the data from US National Health and Nutrition Examination Surveys (NHANES) and the Global Burden of Disease 2019 database. Results A total of 98 studies, involving a combined population of 16,418,361 individuals, were included in the analysis. Among the included studies, 57 focused on breast cancer, 17 on lung cancer, 23 on colon cancer, 5 on gastric cancer, and 7 on liver cancer. Overall, elevated levels of physical activity exhibited an inverse correlation with the risk of cancer. The dose‐response curve for lung cancer exhibited a non‐linear pattern, with the greatest benefit risk reduction observed at 13,200 MET‐minutes/week of physical activity, resulting in a 14.7% reduction in risk (relative risk 0.853, uncertainty interval 0.798 to 0.912) compared to the inactive population. In contrast, the dose‐response curves for colon, gastric, breast, and liver cancers showed linear associations, indicating that heightened levels of total physical activity were consistently associated with reduced cancer risks. However, the increase in physical activity yielded a smaller risk reduction for colon and gastric cancers compared to breast and liver cancers. Compared to individuals with insufficient activity (total activity level < 600 MET‐minutes/week), individuals with high levels of activity (≥ 8,000 MET‐minutes/week) experienced a 10.3% (0.897, 0.860 to 0.934) risk reduction for breast cancer; 5.9% (0.941, 0.884 to 1.001) for lung cancer; 7.1% (0.929, 0.909 to 0.949) for colon cancer; 5.1% (0.949, 0.908 to 0.992) for gastric cancer; 17.1% (0.829, 0.760 to 0.903) for liver cancer. Conclusions This study demonstrated a significant inverse relationship between total physical activity and the risk of breast, gastric, liver, colon, and lung cancers.https://doi.org/10.1002/cac2.12488cancer riskdose‐response analysisGlobal Burden of Diseasephysical activity |
| spellingShingle | Xiayao Diao Yudong Ling Yi Zeng Yueqian Wu Chao Guo Yukai Jin Xiaojiang Chen Shoucheng Feng Jianrong Guo Chao Ding Feiyu Diao Zhicheng Du Shanqing Li Haibo Qiu Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 Cancer Communications cancer risk dose‐response analysis Global Burden of Disease physical activity |
| title | Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 |
| title_full | Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 |
| title_fullStr | Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 |
| title_full_unstemmed | Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 |
| title_short | Physical activity and cancer risk: a dose‐response analysis for the Global Burden of Disease Study 2019 |
| title_sort | physical activity and cancer risk a dose response analysis for the global burden of disease study 2019 |
| topic | cancer risk dose‐response analysis Global Burden of Disease physical activity |
| url | https://doi.org/10.1002/cac2.12488 |
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