Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients
Purpose: We aimed at assessing the impact of surveillance on long-term survival in HCC patients. Methods: From the ITA.LI.CA database, we selected 1028 cases with long (≥5 years, LS group) and 2721 controls with short-term survival (<5 years, SS group). The association between surveillance and LS...
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MDPI AG
2021-02-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/13/4/897 |
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author | Filippo Pelizzaro Alessandro Vitale Anna Sartori Andrea Vieno Barbara Penzo Francesco Paolo Russo Anna Chiara Frigo Edoardo G Giannini Manuela Piccinnu Gian Ludovico Rapaccini Maria Di Marco Eugenio Caturelli Marco Zoli Rodolfo Sacco Ciro Celsa Fabio Marra Andrea Mega Maria Guarino Antonio Gasbarrini Gianluca Svegliati-Baroni Francesco Giuseppe Foschi Andrea Olivani Alberto Masotto Pietro Coccoli Giovanni Raimondo Francesco Azzaroli Gianpaolo Vidili Maurizia Rossana Brunetto Franco Trevisani Fabio Farinati on behalf of ITA.LI.CA Study Group |
author_facet | Filippo Pelizzaro Alessandro Vitale Anna Sartori Andrea Vieno Barbara Penzo Francesco Paolo Russo Anna Chiara Frigo Edoardo G Giannini Manuela Piccinnu Gian Ludovico Rapaccini Maria Di Marco Eugenio Caturelli Marco Zoli Rodolfo Sacco Ciro Celsa Fabio Marra Andrea Mega Maria Guarino Antonio Gasbarrini Gianluca Svegliati-Baroni Francesco Giuseppe Foschi Andrea Olivani Alberto Masotto Pietro Coccoli Giovanni Raimondo Francesco Azzaroli Gianpaolo Vidili Maurizia Rossana Brunetto Franco Trevisani Fabio Farinati on behalf of ITA.LI.CA Study Group |
author_sort | Filippo Pelizzaro |
collection | DOAJ |
description | Purpose: We aimed at assessing the impact of surveillance on long-term survival in HCC patients. Methods: From the ITA.LI.CA database, we selected 1028 cases with long (≥5 years, LS group) and 2721 controls with short-term survival (<5 years, SS group). The association between surveillance and LS was adjusted for confounders by multivariable logistic regression analysis. Survival of surveilled patients was presented both as observed and corrected for the lead-time bias, and the comparison of survival between surveillance and no surveillance groups was also performed after balancing the baseline characteristics with inverse probability weights (IPW). Results: LS patients were more frequently diagnosed under surveillance (<i>p</i> < 0.0001), and had more favorable baseline characteristics. Surveillance was an independent predictor of LS (OR = 1.413, 95% CI 1.195–1.671; <i>p</i> < 0.0001). The observed and the lead-time corrected survival of surveilled patients were significantly longer compared to the survival of not surveilled patients (<i>p</i> < 0.0001 and <i>p</i> = 0.0008, respectively). In IPW adjusted populations, no survival differences were demonstrated between the two groups (<i>p</i> = 0.30). Conclusions: Surveillance, increasing early-stage diagnosis and applicability of curative treatments, is a fundamental determinant of long-term survival in HCC patients. A wide implementation of surveillance programs should be pursued in order to improve HCC patients’ prognosis. |
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spelling | doaj.art-e3a612b8c9e641568bb7d9fc21d3e39d2023-12-11T17:49:45ZengMDPI AGCancers2072-66942021-02-0113489710.3390/cancers13040897Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma PatientsFilippo Pelizzaro0Alessandro Vitale1Anna Sartori2Andrea Vieno3Barbara Penzo4Francesco Paolo Russo5Anna Chiara Frigo6Edoardo G Giannini7Manuela Piccinnu8Gian Ludovico Rapaccini9Maria Di Marco10Eugenio Caturelli11Marco Zoli12Rodolfo Sacco13Ciro Celsa14Fabio Marra15Andrea Mega16Maria Guarino17Antonio Gasbarrini18Gianluca Svegliati-Baroni19Francesco Giuseppe Foschi20Andrea Olivani21Alberto Masotto22Pietro Coccoli23Giovanni Raimondo24Francesco Azzaroli25Gianpaolo Vidili26Maurizia Rossana Brunetto27Franco Trevisani28Fabio Farinati29on behalf of ITA.LI.CA Study GroupGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyHepatobiliary Surgery and Liver Transplantation Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyBiostatistics Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, 35128 Padova, ItalyGastroenterology Unit, Department of Internal Medicine, University of Genova, IRCCS Policlinico San Martino, 16132 Genova, ItalyInternal Medicine–Piscaglia Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, ItalyGastroenterology Unit, Fondazione Policlinico Universitario A. Gemelli, IRCCS, 00168 Roma, ItalyMedicine Unit, Bolognini Hospital, 24068 Seriate, ItalyGastroenterology Unit, Belcolle Hospital, 01100 Viterbo, ItalyInternal Medicine–Zoli Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, ItalyGastroenterology and Digestive Endoscopy Unit, Foggia University Hospital, 71122 Foggia, ItalyGastroenterology & Hepatology Unit, Department of Health Promotion, Mother & Child Care, Internal Medicine & Medical Specialties, PROMISE, University of Palermo, 90133 Palermo, ItalyInternal Medicine and Hepatology Unit, Department of Experimental and Clinical Medicine, University of Firenze, 50121 Firenze, ItalyGastroenterology Unit, Bolzano Regional Hospital, 39100 Bolzano, ItalyGastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli “Federico II”, 80138 Napoli, ItalyInternal Medicine and Gastroenterology Unit, Policlinico Gemelli, Università Cattolica del Sacro Cuore, 00168 Roma, ItalyGastroenterology Unit, Polytechnic University of Marche, 60121 Ancona, ItalyDepartment of Internal Medicine, Ospedale per gli Infermi di Faenza, 48018 Faenza, ItalyInfectious Diseases and Hepatology Unit, Azienda Ospedaliero-Universitaria di Parma, 43126 Parma, ItalyGastroenterology Unit, Ospedale Sacro Cuore Don Calabria, 37024 Negrar, ItalyHepato-Gastroenterology Unit, Department of Clinical Medicine and Surgery, University of Napoli “Federico II”, 80138 Napoli, ItalyClinical and Molecular Hepatology Unit, Department of Clinical and Experimental Medicine, University of Messina, 98122 Messina, ItalyGastroenterology Unit, Department of Surgical and Medical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40126 Bologna, ItalyClinica Medica Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Azienda Ospedaliero-Universitaria di Sassari, 07100 Sassari, ItalyDepartment of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine, University of Pisa, 56126 Pisa, ItalyMedical Semeiotics Unit, Department of Medical and Surgical Sciences, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, ItalyGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padova, 35128 Padova, ItalyPurpose: We aimed at assessing the impact of surveillance on long-term survival in HCC patients. Methods: From the ITA.LI.CA database, we selected 1028 cases with long (≥5 years, LS group) and 2721 controls with short-term survival (<5 years, SS group). The association between surveillance and LS was adjusted for confounders by multivariable logistic regression analysis. Survival of surveilled patients was presented both as observed and corrected for the lead-time bias, and the comparison of survival between surveillance and no surveillance groups was also performed after balancing the baseline characteristics with inverse probability weights (IPW). Results: LS patients were more frequently diagnosed under surveillance (<i>p</i> < 0.0001), and had more favorable baseline characteristics. Surveillance was an independent predictor of LS (OR = 1.413, 95% CI 1.195–1.671; <i>p</i> < 0.0001). The observed and the lead-time corrected survival of surveilled patients were significantly longer compared to the survival of not surveilled patients (<i>p</i> < 0.0001 and <i>p</i> = 0.0008, respectively). In IPW adjusted populations, no survival differences were demonstrated between the two groups (<i>p</i> = 0.30). Conclusions: Surveillance, increasing early-stage diagnosis and applicability of curative treatments, is a fundamental determinant of long-term survival in HCC patients. A wide implementation of surveillance programs should be pursued in order to improve HCC patients’ prognosis.https://www.mdpi.com/2072-6694/13/4/897hepatocellular carcinomalong-term survivalsurveillancecancer stagetreatment |
spellingShingle | Filippo Pelizzaro Alessandro Vitale Anna Sartori Andrea Vieno Barbara Penzo Francesco Paolo Russo Anna Chiara Frigo Edoardo G Giannini Manuela Piccinnu Gian Ludovico Rapaccini Maria Di Marco Eugenio Caturelli Marco Zoli Rodolfo Sacco Ciro Celsa Fabio Marra Andrea Mega Maria Guarino Antonio Gasbarrini Gianluca Svegliati-Baroni Francesco Giuseppe Foschi Andrea Olivani Alberto Masotto Pietro Coccoli Giovanni Raimondo Francesco Azzaroli Gianpaolo Vidili Maurizia Rossana Brunetto Franco Trevisani Fabio Farinati on behalf of ITA.LI.CA Study Group Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients Cancers hepatocellular carcinoma long-term survival surveillance cancer stage treatment |
title | Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients |
title_full | Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients |
title_fullStr | Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients |
title_full_unstemmed | Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients |
title_short | Surveillance as Determinant of Long-Term Survival in Non-Transplanted Hepatocellular Carcinoma Patients |
title_sort | surveillance as determinant of long term survival in non transplanted hepatocellular carcinoma patients |
topic | hepatocellular carcinoma long-term survival surveillance cancer stage treatment |
url | https://www.mdpi.com/2072-6694/13/4/897 |
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