Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study

Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study

Abstract Background Pathogenic germline mutations in BRCA1 and BRCA2 (BRCA1/2) account for the majority of hereditary breast and/or ovarian cancers worldwide. To refine the spectrum of BRCA1/2 mutations and to accurately estimate the prevalence of mutation in the Pakistani population, we studied 539...

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Bibliographic Details
Main Authors: Muhammad Usman Rashid, Noor Muhammad, Humaira Naeemi, Faiz Ali Khan, Mariam Hassan, Saima Faisal, Sidra Gull, Asim Amin, Asif Loya, Ute Hamann
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Hereditary Cancer in Clinical Practice
Subjects:
BRCA1/2
germline mutations
breast cancer
Pakistan
Online Access:http://link.springer.com/article/10.1186/s13053-019-0125-5

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