Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

In skeletal muscle, transforming growth factor-β (TGF-β) family growth factors, TGF-β1 and myostatin, are involved in atrophy and muscle wasting disorders. Simultaneous interference with their signalling pathways may improve muscle function; however, little is known about their individual and combin...

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Bibliographic Details
Main Authors: Michèle MG Hillege, Andi Shi, Ricardo A Galli, Gang Wu, Philippe Bertolino, Willem MH Hoogaars, Richard T Jaspers
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
TGF-β
myostatin
type I receptor
hypertrophy
injury
skeletal muscle
Online Access:https://elifesciences.org/articles/77610

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