| Summary: | According to recent studies, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have shown a good antimicrobial and antifungal activity. Their association with essential oils (EOs) could be useful for the treatment of infections caused by <i>Candida spp</i>. The aim of this studyis to evaluate the synergistic antifungal activity of new combinations between Diclofenac Sodium Salt (DSS), a widely used NSAID, with EOs of <i>Mentha × piperita</i>, <i>Pelargonium graveolens</i> and <i>Melaleuca alternifolia</i>. The in-vitro antifungal activity was determined on different <i>Candida</i> strains. The determination of the chemical composition of EOs was carried out by gaschromatography-massspectrometry (GC-MS). Susceptibility testing of planktonic cells was performed by using the broth microdilution assay and checkerboard methods. Minimum Inhibitory Concentrations (MIC) of DSS was in a range from 1.02 to 2.05 μg/mL reaching a MIC value of 0.05 μg/mL when combined with <i>Pelargonium graveolens</i> (FICI = 0.23–0.35) or <i>Menthapiperita</i> (FICI = 0.22–0.30) EOs. These preliminary results show thatthe combination of the EOs with DSS improves the antifungal activity on all the tested <i>Candida</i> strains.
|
|---|