Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology
Essential oils (EOs) are a complex mixture of hydrophobic and volatile compounds synthesized from aromatic plants, most of them commonly used in the human diet. In recent years, many studies have analyzed their antimicrobial, antioxidant, anti-inflammatory, immunomodulatory and anticancer properties...
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MDPI AG
2020-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/4152 |
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| author | Enzo Spisni Giovannamaria Petrocelli Veronica Imbesi Renato Spigarelli Demetrio Azzinnari Marco Donati Sarti Massimo Campieri Maria Chiara Valerii |
| author_facet | Enzo Spisni Giovannamaria Petrocelli Veronica Imbesi Renato Spigarelli Demetrio Azzinnari Marco Donati Sarti Massimo Campieri Maria Chiara Valerii |
| author_sort | Enzo Spisni |
| collection | DOAJ |
| description | Essential oils (EOs) are a complex mixture of hydrophobic and volatile compounds synthesized from aromatic plants, most of them commonly used in the human diet. In recent years, many studies have analyzed their antimicrobial, antioxidant, anti-inflammatory, immunomodulatory and anticancer properties in vitro and on experimentally induced animal models of colitis and colorectal cancer. However, there are still few clinical studies aimed to understand their role in the modulation of the intestinal pathophysiology. Many EOs and some of their molecules have demonstrated their efficacy in inhibiting bacterial, fungi and virus replication and in modulating the inflammatory and oxidative processes that take place in experimental colitis. In addition to this, their antitumor activity against colorectal cancer models makes them extremely interesting compounds for the modulation of the pathophysiology of the large bowel. The characterization of these EOs is made difficult by their complexity and by the different compositions present in the same oil having different geographical origins. This review tries to shift the focus from the EOs to their individual compounds, to expand their possible applications in modulating colon pathophysiology. |
| first_indexed | 2024-03-10T19:15:29Z |
| format | Article |
| id | doaj.art-e3af136c2daf432097051c749c9ceb87 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:15:29Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e3af136c2daf432097051c749c9ceb872023-11-20T03:27:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012111415210.3390/ijms21114152Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic PathophysiologyEnzo Spisni0Giovannamaria Petrocelli1Veronica Imbesi2Renato Spigarelli3Demetrio Azzinnari4Marco Donati Sarti5Massimo Campieri6Maria Chiara Valerii7Department of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Biological, Geological and Environmental Sciences, University of Bologna, Via Selmi 3, 40126 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyEssential oils (EOs) are a complex mixture of hydrophobic and volatile compounds synthesized from aromatic plants, most of them commonly used in the human diet. In recent years, many studies have analyzed their antimicrobial, antioxidant, anti-inflammatory, immunomodulatory and anticancer properties in vitro and on experimentally induced animal models of colitis and colorectal cancer. However, there are still few clinical studies aimed to understand their role in the modulation of the intestinal pathophysiology. Many EOs and some of their molecules have demonstrated their efficacy in inhibiting bacterial, fungi and virus replication and in modulating the inflammatory and oxidative processes that take place in experimental colitis. In addition to this, their antitumor activity against colorectal cancer models makes them extremely interesting compounds for the modulation of the pathophysiology of the large bowel. The characterization of these EOs is made difficult by their complexity and by the different compositions present in the same oil having different geographical origins. This review tries to shift the focus from the EOs to their individual compounds, to expand their possible applications in modulating colon pathophysiology.https://www.mdpi.com/1422-0067/21/11/4152essential oilsbowelantioxidantanti-inflammatorymicrobial-modulatingcolorectal cancer |
| spellingShingle | Enzo Spisni Giovannamaria Petrocelli Veronica Imbesi Renato Spigarelli Demetrio Azzinnari Marco Donati Sarti Massimo Campieri Maria Chiara Valerii Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology International Journal of Molecular Sciences essential oils bowel antioxidant anti-inflammatory microbial-modulating colorectal cancer |
| title | Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology |
| title_full | Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology |
| title_fullStr | Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology |
| title_full_unstemmed | Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology |
| title_short | Antioxidant, Anti-Inflammatory, and Microbial-Modulating Activities of Essential Oils: Implications in Colonic Pathophysiology |
| title_sort | antioxidant anti inflammatory and microbial modulating activities of essential oils implications in colonic pathophysiology |
| topic | essential oils bowel antioxidant anti-inflammatory microbial-modulating colorectal cancer |
| url | https://www.mdpi.com/1422-0067/21/11/4152 |
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