Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies
Manganese (Mn) exposure has evolved from acute, high-level exposure causing manganism to low, chronic lifetime exposure. In this latter scenario, the target areas extend beyond the globus pallidus (as seen with manganism) to the entire basal ganglia, including the substantia nigra pars compacta. Thi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/8/1190 |
| _version_ | 1797585422542438400 |
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| author | Roberto Lucchini Kim Tieu |
| author_facet | Roberto Lucchini Kim Tieu |
| author_sort | Roberto Lucchini |
| collection | DOAJ |
| description | Manganese (Mn) exposure has evolved from acute, high-level exposure causing manganism to low, chronic lifetime exposure. In this latter scenario, the target areas extend beyond the globus pallidus (as seen with manganism) to the entire basal ganglia, including the substantia nigra pars compacta. This change of exposure paradigm has prompted numerous epidemiological investigations of the occurrence of Parkinson’s disease (PD), or parkinsonism, due to the long-term impact of Mn. In parallel, experimental research has focused on the underlying pathogenic mechanisms of Mn and its interactions with genetic susceptibility. In this review, we provide evidence from both types of studies, with the aim to link the epidemiological data with the potential mechanistic interpretation. |
| first_indexed | 2024-03-11T00:05:53Z |
| format | Article |
| id | doaj.art-e3af3f4dc0a7488083b251a4ca8d2018 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T00:05:53Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-e3af3f4dc0a7488083b251a4ca8d20182023-11-19T00:23:30ZengMDPI AGBiomolecules2218-273X2023-07-01138119010.3390/biom13081190Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental StudiesRoberto Lucchini0Kim Tieu1Department of Environmental Health Sciences, Florida International University, Miami, FL 33199, USADepartment of Environmental Health Sciences, Florida International University, Miami, FL 33199, USAManganese (Mn) exposure has evolved from acute, high-level exposure causing manganism to low, chronic lifetime exposure. In this latter scenario, the target areas extend beyond the globus pallidus (as seen with manganism) to the entire basal ganglia, including the substantia nigra pars compacta. This change of exposure paradigm has prompted numerous epidemiological investigations of the occurrence of Parkinson’s disease (PD), or parkinsonism, due to the long-term impact of Mn. In parallel, experimental research has focused on the underlying pathogenic mechanisms of Mn and its interactions with genetic susceptibility. In this review, we provide evidence from both types of studies, with the aim to link the epidemiological data with the potential mechanistic interpretation.https://www.mdpi.com/2218-273X/13/8/1190manganesemanganismneurotoxicityparkinsonismParkinson’s diseasegene-environment interaction |
| spellingShingle | Roberto Lucchini Kim Tieu Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies Biomolecules manganese manganism neurotoxicity parkinsonism Parkinson’s disease gene-environment interaction |
| title | Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies |
| title_full | Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies |
| title_fullStr | Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies |
| title_full_unstemmed | Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies |
| title_short | Manganese-Induced Parkinsonism: Evidence from Epidemiological and Experimental Studies |
| title_sort | manganese induced parkinsonism evidence from epidemiological and experimental studies |
| topic | manganese manganism neurotoxicity parkinsonism Parkinson’s disease gene-environment interaction |
| url | https://www.mdpi.com/2218-273X/13/8/1190 |
| work_keys_str_mv | AT robertolucchini manganeseinducedparkinsonismevidencefromepidemiologicalandexperimentalstudies AT kimtieu manganeseinducedparkinsonismevidencefromepidemiologicalandexperimentalstudies |