DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines

DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Due to abundant stroma and extracellular matrix, accompanied by lack of vascularization, pancreatic ductal adenocarcinoma (PDAC) is characterized by severe hypoxia. Epigenetic regulation is likely one of the mechanisms driving hypoxia-induced epithelial-to-mesenchymal transition (EMT), responsible f...

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Bibliographic Details
Main Authors: Maria Urbanova, Verona Buocikova, Lenka Trnkova, Sabina Strapcova, Viera Horvathova Kajabova, Emma Barreto Melian, Maria Novisedlakova, Miroslav Tomas, Peter Dubovan, Julie Earl, Jozef Bizik, Eliska Svastova, Sona Ciernikova, Bozena Smolkova
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
PDAC
inflammation
hypoxia
epithelial-to-mesenchymal transition
DNA methylation
Online Access:https://www.mdpi.com/1422-0067/23/4/2117

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