The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia

The Yin and Yang of the Bone Marrow Microenvironment: Pros and Cons of Mesenchymal Stromal Cells in Acute Myeloid Leukemia

Mesenchymal stromal cells (MSCs) have, for a long time, been recognized as pivotal contributors in the set up and maintenance of the hematopoietic stem cell (HSC) niche, as well as in the development and differentiation of the lympho-hematopoietic system. MSCs also have a unique immunomodulatory cap...

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Bibliographic Details
Main Authors: Marilena Ciciarello, Giulia Corradi, Federica Loscocco, Giuseppe Visani, Federica Monaco, Michele Cavo, Antonio Curti, Alessandro Isidori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
mesenchymal stromal cells
bone marrow microenvironment
drug resistance
immunomodulation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01135/full

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