Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response

Sex differences in a double-blind randomized clinical trial with minocycline in treatment-resistant depressed patients: CRP and IL-6 as sex-specific predictors of treatment response

Background: Inflammation is a well-known risk factor for depression. Specifically, patients who do not respond to antidepressant treatment show higher levels of inflammatory biomarkers compared with responders. Thus, several studies have investigated the efficacy of anti-inflammatory add-on treatmen...

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Détails bibliographiques
Auteurs principaux: Giulia Lombardo, Maria Antonietta Nettis, Caitlin Hastings, Zuzanna Zajkowska, Nicole Mariani, Naghmeh Nikkheslat, Courtney Worrell, Daniela Enache, Anna McLaughlin, Melisa Kose, Anna Bogdanova, Luca Sforzini, Anthony J. Cleare, Allan H. Young, Paola Dazzan, Valeria Mondelli, Carmine M. Pariante
Format: Article
Langue:English
Publié: Elsevier 2022-12-01
Collection:Brain, Behavior, & Immunity - Health
Sujets:
Minocycline
Major depressive disorder
Treatment resistant depression
Sex differences
C-Reactive protein
Interleukin 6
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S266635462200151X

Internet

http://www.sciencedirect.com/science/article/pii/S266635462200151X

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