The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients
The co-occurrence of tuberculosis (TB) and diabetes mellitus (DM) presents a significant obstacle to TB eradication. Pulmonary cavitation can occur in severe cases of TB, particularly in patients with DM. From 1 May 2014 through 30 June 2019, we conducted a cross-sectional study of 1,658 smear- or c...
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1245316/full |
| _version_ | 1797403367760199680 |
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| author | Min Yang Pei Li Han Liu Xiaojie Zhu Guofeng Zhu Peize Zhang Guofang Deng |
| author_facet | Min Yang Pei Li Han Liu Xiaojie Zhu Guofeng Zhu Peize Zhang Guofang Deng |
| author_sort | Min Yang |
| collection | DOAJ |
| description | The co-occurrence of tuberculosis (TB) and diabetes mellitus (DM) presents a significant obstacle to TB eradication. Pulmonary cavitation can occur in severe cases of TB, particularly in patients with DM. From 1 May 2014 through 30 June 2019, we conducted a cross-sectional study of 1,658 smear- or culture-confirmed pulmonary TB (PTB) patients at the Second Department of Pulmonary Medicine and Tuberculosis, Shenzhen, China. A total of 861 participants who satisfied the criteria (chest CT scan for cavitation, interferon-gamma release assay (IGRA), diagnosis of diabetes mellitus), with the median age of 36.7 years, 63.6% of male, 79.7% IGRA positive, 13.8% with diabetes, and 40.8% with pulmonary cavitation, were included in the study. The association between diabetes and pulmonary cavitation was confirmed in these TB patients (adjusted OR, 2.54; 95% CI, 1.66–3.94; p < 0.001). No associations were observed between diabetes and IGRA, as well as between lung cavitary and IGRA. Based on the criteria of IGRA+/–, pulmonary cavitation+/–, and DM+/–, the further analysis with univariate and multivariate logistic regression were conducted in six subgroups. The significant association between diabetes and pulmonary cavitation was further confirmed in the IGRA+ subgroup (adjusted OR, 3.07; 95% CI, 1.86–5.16; p < 0.001) but not observed in IGRA- individuals. This observation suggests that different immunological mechanisms of pulmonary cavitary/DM may be employed in IGRA+ TB patients from IGRA- TB patients. |
| first_indexed | 2024-03-09T02:37:56Z |
| format | Article |
| id | doaj.art-e3b2f7d928d54218ab7b78fbb3d261e6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-09T02:37:56Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e3b2f7d928d54218ab7b78fbb3d261e62023-12-06T08:19:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-12-011010.3389/fmed.2023.12453161245316The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patientsMin Yang0Pei Li1Han Liu2Xiaojie Zhu3Guofeng Zhu4Peize Zhang5Guofang Deng6Department of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaChina Institute of Veterinary Drug Control, Beijing, ChinaDepartment of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaDepartment of Pulmonary Medicine and Tuberculosis, National Clinical Research Center for Infectious Diseases, Guangdong Provincial Clinical Research Center for Infectious Diseases (Tuberculosis), Shenzhen Clinical Research Center for Tuberculosis, The Third People's Hospital of Shenzhen, Southern University of Science and Technology, Shenzhen, ChinaThe co-occurrence of tuberculosis (TB) and diabetes mellitus (DM) presents a significant obstacle to TB eradication. Pulmonary cavitation can occur in severe cases of TB, particularly in patients with DM. From 1 May 2014 through 30 June 2019, we conducted a cross-sectional study of 1,658 smear- or culture-confirmed pulmonary TB (PTB) patients at the Second Department of Pulmonary Medicine and Tuberculosis, Shenzhen, China. A total of 861 participants who satisfied the criteria (chest CT scan for cavitation, interferon-gamma release assay (IGRA), diagnosis of diabetes mellitus), with the median age of 36.7 years, 63.6% of male, 79.7% IGRA positive, 13.8% with diabetes, and 40.8% with pulmonary cavitation, were included in the study. The association between diabetes and pulmonary cavitation was confirmed in these TB patients (adjusted OR, 2.54; 95% CI, 1.66–3.94; p < 0.001). No associations were observed between diabetes and IGRA, as well as between lung cavitary and IGRA. Based on the criteria of IGRA+/–, pulmonary cavitation+/–, and DM+/–, the further analysis with univariate and multivariate logistic regression were conducted in six subgroups. The significant association between diabetes and pulmonary cavitation was further confirmed in the IGRA+ subgroup (adjusted OR, 3.07; 95% CI, 1.86–5.16; p < 0.001) but not observed in IGRA- individuals. This observation suggests that different immunological mechanisms of pulmonary cavitary/DM may be employed in IGRA+ TB patients from IGRA- TB patients.https://www.frontiersin.org/articles/10.3389/fmed.2023.1245316/fulltuberculosisdiabetes mellituspulmonary cavitationinterferon-gammarisk factor |
| spellingShingle | Min Yang Pei Li Han Liu Xiaojie Zhu Guofeng Zhu Peize Zhang Guofang Deng The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients Frontiers in Medicine tuberculosis diabetes mellitus pulmonary cavitation interferon-gamma risk factor |
| title | The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients |
| title_full | The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients |
| title_fullStr | The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients |
| title_full_unstemmed | The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients |
| title_short | The association between type 2 diabetes and pulmonary cavitation revealed among IGRA-positive tuberculosis patients |
| title_sort | association between type 2 diabetes and pulmonary cavitation revealed among igra positive tuberculosis patients |
| topic | tuberculosis diabetes mellitus pulmonary cavitation interferon-gamma risk factor |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1245316/full |
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