GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function

GM-CSF promotes myeloid differentiation of cultured bone marrow cells into cells of the granulocytic and monocytic lineage; the latter can further differentiate into monocytes/macrophages and dendritic cells. How GM-CSF selects for these different myeloid fates is unresolved. GM-CSF levels can chang...

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Bibliographic Details
Main Authors: Li Sun, Jai Rautela, Rebecca B. Delconte, Fernando Souza-Fonseca-Guimaraes, Emma M. Carrington, Robyn L. Schenk, Marco J. Herold, Nicholas D. Huntington, Andrew M. Lew, Yuekang Xu, Yifan Zhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
GM-CSF
dendritic cells
inflammation mediators
granulocytes
cytokines
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01922/full

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