Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients
ObjectiveLeveraging the Manhattan Lupus Surveillance Program (MLSP), a population-based registry of cases of systemic lupus erythematosus (SLE) and related diseases, we investigated the proportion of SLE with concomitant rheumatic diseases, including Sjögren’s disease (SjD), antiphospholipid syndrom...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Epidemiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fepid.2024.1334859/full |
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| author | Brendan Denvir Philip M. Carlucci Kelly Corbitt Jill P. Buyon H. Michael Belmont Heather T. Gold Jane E. Salmon Anca Askanase Joan M. Bathon Laura Geraldino-Pardilla Yousaf Ali Ellen M. Ginzler Chaim Putterman Caroline Gordon Kamil E. Barbour Charles G. Helmick Hilary Parton Peter M. Izmirly |
| author_facet | Brendan Denvir Philip M. Carlucci Kelly Corbitt Jill P. Buyon H. Michael Belmont Heather T. Gold Jane E. Salmon Anca Askanase Joan M. Bathon Laura Geraldino-Pardilla Yousaf Ali Ellen M. Ginzler Chaim Putterman Caroline Gordon Kamil E. Barbour Charles G. Helmick Hilary Parton Peter M. Izmirly |
| author_sort | Brendan Denvir |
| collection | DOAJ |
| description | ObjectiveLeveraging the Manhattan Lupus Surveillance Program (MLSP), a population-based registry of cases of systemic lupus erythematosus (SLE) and related diseases, we investigated the proportion of SLE with concomitant rheumatic diseases, including Sjögren’s disease (SjD), antiphospholipid syndrome (APLS), and fibromyalgia (FM), as well as the prevalence of autoantibodies in SLE by sex and race/ethnicity.MethodsPrevalent SLE cases fulfilled one of three sets of classification criteria. Additional rheumatic diseases were defined using modified criteria based on data available in the MLSP: SjD (anti-SSA/Ro positive and evidence of keratoconjunctivitis sicca and/or xerostomia), APLS (antiphospholipid antibody positive and evidence of a blood clot), and FM (diagnosis in the chart).Results1,342 patients fulfilled SLE classification criteria. Of these, SjD was identified in 147 (11.0%, 95% CI 9.2–12.7%) patients with women and non-Latino Asian patients being the most highly represented. APLS was diagnosed in 119 (8.9%, 95% CI 7.3–10.5%) patients with the highest frequency in Latino patients. FM was present in 120 (8.9%, 95% CI 7.3–10.5) patients with non-Latino White and Latino patients having the highest frequency. Anti-dsDNA antibodies were most prevalent in non-Latino Asian, Black, and Latino patients while anti-Sm antibodies showed the highest proportion in non-Latino Black and Asian patients. Anti-SSA/Ro and anti-SSB/La antibodies were most prevalent in non-Latino Asian patients and least prevalent in non-Latino White patients. Men were more likely to be anti-Sm positive.ConclusionData from the MLSP revealed differences among patients classified as SLE in the prevalence of concomitant rheumatic diseases and autoantibody profiles by sex and race/ethnicity underscoring comorbidities associated with SLE. |
| first_indexed | 2024-03-07T14:31:29Z |
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| issn | 2674-1199 |
| language | English |
| last_indexed | 2025-03-21T00:21:56Z |
| publishDate | 2024-03-01 |
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| series | Frontiers in Epidemiology |
| spelling | doaj.art-e3b479c4958641598efa1d20dfa4338b2024-08-03T08:17:49ZengFrontiers Media S.A.Frontiers in Epidemiology2674-11992024-03-01410.3389/fepid.2024.13348591334859Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patientsBrendan Denvir0Philip M. Carlucci1Kelly Corbitt2Jill P. Buyon3H. Michael Belmont4Heather T. Gold5Jane E. Salmon6Anca Askanase7Joan M. Bathon8Laura Geraldino-Pardilla9Yousaf Ali10Ellen M. Ginzler11Chaim Putterman12Caroline Gordon13Kamil E. Barbour14Charles G. Helmick15Hilary Parton16Peter M. Izmirly17Department of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesDepartment of Population Health, New York University Grossman School of Medicine, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDivision of Rheumatology, Department of Medicine, SUNY Downstate Health Sciences University, Brooklyn, NY, United StatesAzrieli Faculty of Medicine, Zefat, IsraelRheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom0Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States0Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States1Division of Disease Control, Bureau of Communicable Disease, New York City Department of Health and Mental Hygiene, Long Island City, NY, United StatesDivision of Rheumatology, Department of Medicine, New York University Grossman School of Medicine, New York, NY, United StatesObjectiveLeveraging the Manhattan Lupus Surveillance Program (MLSP), a population-based registry of cases of systemic lupus erythematosus (SLE) and related diseases, we investigated the proportion of SLE with concomitant rheumatic diseases, including Sjögren’s disease (SjD), antiphospholipid syndrome (APLS), and fibromyalgia (FM), as well as the prevalence of autoantibodies in SLE by sex and race/ethnicity.MethodsPrevalent SLE cases fulfilled one of three sets of classification criteria. Additional rheumatic diseases were defined using modified criteria based on data available in the MLSP: SjD (anti-SSA/Ro positive and evidence of keratoconjunctivitis sicca and/or xerostomia), APLS (antiphospholipid antibody positive and evidence of a blood clot), and FM (diagnosis in the chart).Results1,342 patients fulfilled SLE classification criteria. Of these, SjD was identified in 147 (11.0%, 95% CI 9.2–12.7%) patients with women and non-Latino Asian patients being the most highly represented. APLS was diagnosed in 119 (8.9%, 95% CI 7.3–10.5%) patients with the highest frequency in Latino patients. FM was present in 120 (8.9%, 95% CI 7.3–10.5) patients with non-Latino White and Latino patients having the highest frequency. Anti-dsDNA antibodies were most prevalent in non-Latino Asian, Black, and Latino patients while anti-Sm antibodies showed the highest proportion in non-Latino Black and Asian patients. Anti-SSA/Ro and anti-SSB/La antibodies were most prevalent in non-Latino Asian patients and least prevalent in non-Latino White patients. Men were more likely to be anti-Sm positive.ConclusionData from the MLSP revealed differences among patients classified as SLE in the prevalence of concomitant rheumatic diseases and autoantibody profiles by sex and race/ethnicity underscoring comorbidities associated with SLE.https://www.frontiersin.org/articles/10.3389/fepid.2024.1334859/fullsystemic lupus erythematosusSjögren's diseaseantiphospholipid syndromefibromyalgiaautoantibodies |
| spellingShingle | Brendan Denvir Philip M. Carlucci Kelly Corbitt Jill P. Buyon H. Michael Belmont Heather T. Gold Jane E. Salmon Anca Askanase Joan M. Bathon Laura Geraldino-Pardilla Yousaf Ali Ellen M. Ginzler Chaim Putterman Caroline Gordon Kamil E. Barbour Charles G. Helmick Hilary Parton Peter M. Izmirly Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients Frontiers in Epidemiology systemic lupus erythematosus Sjögren's disease antiphospholipid syndrome fibromyalgia autoantibodies |
| title | Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients |
| title_full | Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients |
| title_fullStr | Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients |
| title_full_unstemmed | Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients |
| title_short | Prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in SLE patients |
| title_sort | prevalence of concomitant rheumatologic diseases and autoantibody specificities among racial and ethnic groups in sle patients |
| topic | systemic lupus erythematosus Sjögren's disease antiphospholipid syndrome fibromyalgia autoantibodies |
| url | https://www.frontiersin.org/articles/10.3389/fepid.2024.1334859/full |
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