Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal
ABSTRACTThe H9N2 influenza virus has become one of the dominant subtypes of influenza virus circulating in poultry, wild birds, and can occasionally cross the mammalian species barrier. Here, we report the first human A/H9N2 in Sub-Saharan Africa. The patient was a child of 16 months' old livin...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1763858 |
| _version_ | 1827320727514120192 |
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| author | Mamadou Malado Jallow Amary Fall Mamadou Aliou Barry Boly Diop Sara Sy Déborah Goudiaby Malick Fall Vincent Enouf Mbayame Ndiaye Niang Ndongo Dia |
| author_facet | Mamadou Malado Jallow Amary Fall Mamadou Aliou Barry Boly Diop Sara Sy Déborah Goudiaby Malick Fall Vincent Enouf Mbayame Ndiaye Niang Ndongo Dia |
| author_sort | Mamadou Malado Jallow |
| collection | DOAJ |
| description | ABSTRACTThe H9N2 influenza virus has become one of the dominant subtypes of influenza virus circulating in poultry, wild birds, and can occasionally cross the mammalian species barrier. Here, we report the first human A/H9N2 in Sub-Saharan Africa. The patient was a child of 16 months' old living in the South-West of Senegal. He had no influenza vaccination history and no other disease history. He had symptoms of fever with an auxiliary temperature of 39.1°C. Respiratory symptoms were an intense cough, runny nose and pulmonary crackles. All eight genome segments belonged to the A/H9N2 AIV subtype and the strain characyerized as of low pathogenicity with a RSSR/GLF amino acids motif. Phylogenetic analysis of both complete HA and NA gene segments showed that the A/H9N2 subtype virus from Senegal belonged to the G1 lineage. This human case highlights the weakness of influenza surveillance in animals and the need for enhanced surveillance using a one-health approach. |
| first_indexed | 2024-03-07T17:24:35Z |
| format | Article |
| id | doaj.art-e3b547c211a44ae0a240655adf93fc4c |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:52:14Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-e3b547c211a44ae0a240655adf93fc4c2024-03-11T16:04:24ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-01911092109510.1080/22221751.2020.1763858Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, SenegalMamadou Malado Jallow0Amary Fall1Mamadou Aliou Barry2Boly Diop3Sara Sy4Déborah Goudiaby5Malick Fall6Vincent Enouf7Mbayame Ndiaye Niang8Ndongo Dia9Département de Virologie, Institut Pasteur de Dakar, Dakar, SénégalDépartement de Virologie, Institut Pasteur de Dakar, Dakar, SénégalUnité d'Epidémiologie des maladies infectieuses, Institut Pasteur de Dakar, Dakar, SénégalDivision surveillance épidémiologique et riposte vaccinale du ministère de la Santé et de l'action sociale, Dakar, SenegalDépartement de Virologie, Institut Pasteur de Dakar, Dakar, SénégalDépartement de Virologie, Institut Pasteur de Dakar, Dakar, SénégalDépartement de Biologie Animale, Faculté des Sciences et Techniques, Université Cheikh Anta DIOP de Dakar, Dakar, SénégalInstitut Pasteur Paris, Plateforme P2M, Dakar, SenegalDépartement de Virologie, Institut Pasteur de Dakar, Dakar, SénégalDépartement de Virologie, Institut Pasteur de Dakar, Dakar, SénégalABSTRACTThe H9N2 influenza virus has become one of the dominant subtypes of influenza virus circulating in poultry, wild birds, and can occasionally cross the mammalian species barrier. Here, we report the first human A/H9N2 in Sub-Saharan Africa. The patient was a child of 16 months' old living in the South-West of Senegal. He had no influenza vaccination history and no other disease history. He had symptoms of fever with an auxiliary temperature of 39.1°C. Respiratory symptoms were an intense cough, runny nose and pulmonary crackles. All eight genome segments belonged to the A/H9N2 AIV subtype and the strain characyerized as of low pathogenicity with a RSSR/GLF amino acids motif. Phylogenetic analysis of both complete HA and NA gene segments showed that the A/H9N2 subtype virus from Senegal belonged to the G1 lineage. This human case highlights the weakness of influenza surveillance in animals and the need for enhanced surveillance using a one-health approach.https://www.tandfonline.com/doi/10.1080/22221751.2020.1763858InfluenzaAIVA/H9N2phylogenylow pathogenicity |
| spellingShingle | Mamadou Malado Jallow Amary Fall Mamadou Aliou Barry Boly Diop Sara Sy Déborah Goudiaby Malick Fall Vincent Enouf Mbayame Ndiaye Niang Ndongo Dia Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal Emerging Microbes and Infections Influenza AIV A/H9N2 phylogeny low pathogenicity |
| title | Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal |
| title_full | Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal |
| title_fullStr | Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal |
| title_full_unstemmed | Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal |
| title_short | Genetic characterization of the first detected human case of low pathogenic avian influenza A/H9N2 in sub-Saharan Africa, Senegal |
| title_sort | genetic characterization of the first detected human case of low pathogenic avian influenza a h9n2 in sub saharan africa senegal |
| topic | Influenza AIV A/H9N2 phylogeny low pathogenicity |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1763858 |
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