Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats

Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats

Abstract Background Aortic regurgitation (AR) is a valvular disease that can lead to systolic heart failure. Treatment options besides cardiac surgery are limited and consequently severe AR is associated with higher mortality and morbidity when not operated. In this investigation, we examined the ef...

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Bibliographic Details
Main Authors: Bachar El-Oumeiri, Kathleen Mc Entee, Filippo Annoni, Antoine Herpain, Frédéric Vanden Eynden, Pascal Jespers, Guido Van Nooten, Philippe van de Borne
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Cardiovascular Disorders
Subjects:
Omecamtiv-mecarbil
Aortic regurgitation
Doppler-echocardiography
Wistar rat
Left ventricle
Online Access:http://link.springer.com/article/10.1186/s12872-018-0831-3

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