Risk Factors for Disseminated Coccidioidomycosis, United States
Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2017-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/23/2/16-0505_article |
| _version_ | 1818137088440139776 |
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| author | Camila D. Odio Beatriz E. Marciano John N. Galgiani Steven M. Holland |
| author_facet | Camila D. Odio Beatriz E. Marciano John N. Galgiani Steven M. Holland |
| author_sort | Camila D. Odio |
| collection | DOAJ |
| description | Of 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways. |
| first_indexed | 2024-12-11T09:50:44Z |
| format | Article |
| id | doaj.art-e3b6366bec16498f88074d5b825396a4 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T09:50:44Z |
| publishDate | 2017-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-e3b6366bec16498f88074d5b825396a42022-12-22T01:12:26ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592017-02-0123231131110.3201/eid2302.160505Risk Factors for Disseminated Coccidioidomycosis, United StatesCamila D. OdioBeatriz E. MarcianoJohn N. GalgianiSteven M. HollandOf 150,000 new coccidioidomycosis infections that occur annually in the United States, ≈1% disseminate; one third of those cases are fatal. Immunocompromised hosts have higher rates of dissemination. We identified 8 patients with disseminated coccidioidomycosis who had defects in the interleukin-12/interferon-γ and STAT3 axes, indicating that these are critical host defense pathways.https://wwwnc.cdc.gov/eid/article/23/2/16-0505_articleImmunodeficiencyCoccidioidescoccidioidomycosisIL-12/IFN-γraceethnicity |
| spellingShingle | Camila D. Odio Beatriz E. Marciano John N. Galgiani Steven M. Holland Risk Factors for Disseminated Coccidioidomycosis, United States Emerging Infectious Diseases Immunodeficiency Coccidioides coccidioidomycosis IL-12/IFN-γ race ethnicity |
| title | Risk Factors for Disseminated Coccidioidomycosis, United States |
| title_full | Risk Factors for Disseminated Coccidioidomycosis, United States |
| title_fullStr | Risk Factors for Disseminated Coccidioidomycosis, United States |
| title_full_unstemmed | Risk Factors for Disseminated Coccidioidomycosis, United States |
| title_short | Risk Factors for Disseminated Coccidioidomycosis, United States |
| title_sort | risk factors for disseminated coccidioidomycosis united states |
| topic | Immunodeficiency Coccidioides coccidioidomycosis IL-12/IFN-γ race ethnicity |
| url | https://wwwnc.cdc.gov/eid/article/23/2/16-0505_article |
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