The effect of octopamine on the locust stomatogastric nervous system
Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the loc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/full |
| _version_ | 1818390071354589184 |
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| author | David eRand Daniel eKnebel Daniel eKnebel Amir eAyali Amir eAyali |
| author_facet | David eRand Daniel eKnebel Daniel eKnebel Amir eAyali Amir eAyali |
| author_sort | David eRand |
| collection | DOAJ |
| description | Octopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the locust stomatogastric nervous system (STNS) 36 were studied, and one putative source of OA modulation of the system was identified. 37 Bath application of OA was found to abolish the endogenous rhythmic output of the 38 fully isolated frontal ganglion (FG), while stimulating motor activity of the fully 39 isolated hypocerebral ganglion (HG). OA also induced rhythmic movements in a 40 foregut preparation with intact HG innervation. Complex dose-dependent effects of 41 OA on interconnected FG-HG preparations were seen: 10-5M OA accelerated the 42 rhythmic activity of both the HG and FG in a synchronized manner, while 10-4M OA 43 decreased both rhythms. Intracellular stimulation of an identified octopaminergic 44 dorsal unpaired median (DUM) neuron in the subesophageal ganglion (SEG) was 45 found to exert a similar effect on the FG motor output as that of OA application. Our 46 findings suggest a mechanism of regulation of insect gut patterns and feeding-related 47 behavior during stress and times of high energy demand. |
| first_indexed | 2024-12-14T04:51:48Z |
| format | Article |
| id | doaj.art-e3b68fb5995d4f44917551b4052b9870 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T04:51:48Z |
| publishDate | 2012-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e3b68fb5995d4f44917551b4052b98702022-12-21T23:16:31ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2012-07-01310.3389/fphys.2012.0028829247The effect of octopamine on the locust stomatogastric nervous systemDavid eRand0Daniel eKnebel1Daniel eKnebel2Amir eAyali3Amir eAyali4Tel Aviv UniversityTel Aviv UniversityTel Aviv UniversityTel Aviv UniversityTel Aviv UniversityOctopamine (OA) is a prominent neuromodulator of invertebrate nervous systems, 33 influencing multiple physiological processes. Among its many roles in insects are the 34 initiation and maintenance of various rhythmic behaviors. Here, the neuromodulatory 35 effects of OA on the components of the locust stomatogastric nervous system (STNS) 36 were studied, and one putative source of OA modulation of the system was identified. 37 Bath application of OA was found to abolish the endogenous rhythmic output of the 38 fully isolated frontal ganglion (FG), while stimulating motor activity of the fully 39 isolated hypocerebral ganglion (HG). OA also induced rhythmic movements in a 40 foregut preparation with intact HG innervation. Complex dose-dependent effects of 41 OA on interconnected FG-HG preparations were seen: 10-5M OA accelerated the 42 rhythmic activity of both the HG and FG in a synchronized manner, while 10-4M OA 43 decreased both rhythms. Intracellular stimulation of an identified octopaminergic 44 dorsal unpaired median (DUM) neuron in the subesophageal ganglion (SEG) was 45 found to exert a similar effect on the FG motor output as that of OA application. Our 46 findings suggest a mechanism of regulation of insect gut patterns and feeding-related 47 behavior during stress and times of high energy demand.http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/fullOctopaminecentral pattern generatorsDUM neuronsLocuststomatogastric nervous system |
| spellingShingle | David eRand Daniel eKnebel Daniel eKnebel Amir eAyali Amir eAyali The effect of octopamine on the locust stomatogastric nervous system Frontiers in Physiology Octopamine central pattern generators DUM neurons Locust stomatogastric nervous system |
| title | The effect of octopamine on the locust stomatogastric nervous system |
| title_full | The effect of octopamine on the locust stomatogastric nervous system |
| title_fullStr | The effect of octopamine on the locust stomatogastric nervous system |
| title_full_unstemmed | The effect of octopamine on the locust stomatogastric nervous system |
| title_short | The effect of octopamine on the locust stomatogastric nervous system |
| title_sort | effect of octopamine on the locust stomatogastric nervous system |
| topic | Octopamine central pattern generators DUM neurons Locust stomatogastric nervous system |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00288/full |
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