Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19
The SARS-CoV-2 virus, causing the devastating COVID-19 pandemic, has been reported to affect platelets and cause increased thrombotic events, hinting at the possible bidirectional interactions between platelets and the virus. In this review, we discuss the potential mechanisms underlying the increas...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/18/14133 |
| _version_ | 1797579687217594368 |
|---|---|
| author | Junyi Zhao Xiafan Xu Yifei Gao Yijing Yu Conglei Li |
| author_facet | Junyi Zhao Xiafan Xu Yifei Gao Yijing Yu Conglei Li |
| author_sort | Junyi Zhao |
| collection | DOAJ |
| description | The SARS-CoV-2 virus, causing the devastating COVID-19 pandemic, has been reported to affect platelets and cause increased thrombotic events, hinting at the possible bidirectional interactions between platelets and the virus. In this review, we discuss the potential mechanisms underlying the increased thrombotic events as well as altered platelet count and activity in COVID-19. Inspired by existing knowledge on platelet–pathogen interactions, we propose several potential antiviral strategies that platelets might undertake to combat SARS-CoV-2, including their abilities to internalize the virus, release bioactive molecules to interfere with viral infection, and modulate the functions of immune cells. Moreover, we discuss current and potential platelet-targeted therapeutic strategies in controlling COVID-19, including antiplatelet drugs, anticoagulants, and inflammation-targeting treatments. These strategies have shown promise in clinical settings to alleviate the severity of thrombo-inflammatory complications and reduce the mortality rate among COVID-19 patients. In conclusion, an in-depth understanding of platelet–SARS-CoV-2 interactions may uncover novel mechanisms underlying severe COVID-19 complications and could provide new therapeutic avenues for managing this disease. |
| first_indexed | 2024-03-10T22:40:44Z |
| format | Article |
| id | doaj.art-e3b6924c213f4a34b0cab06aaba82426 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:44Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e3b6924c213f4a34b0cab06aaba824262023-11-19T11:08:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181413310.3390/ijms241814133Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19Junyi Zhao0Xiafan Xu1Yifei Gao2Yijing Yu3Conglei Li4School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, ChinaThe SARS-CoV-2 virus, causing the devastating COVID-19 pandemic, has been reported to affect platelets and cause increased thrombotic events, hinting at the possible bidirectional interactions between platelets and the virus. In this review, we discuss the potential mechanisms underlying the increased thrombotic events as well as altered platelet count and activity in COVID-19. Inspired by existing knowledge on platelet–pathogen interactions, we propose several potential antiviral strategies that platelets might undertake to combat SARS-CoV-2, including their abilities to internalize the virus, release bioactive molecules to interfere with viral infection, and modulate the functions of immune cells. Moreover, we discuss current and potential platelet-targeted therapeutic strategies in controlling COVID-19, including antiplatelet drugs, anticoagulants, and inflammation-targeting treatments. These strategies have shown promise in clinical settings to alleviate the severity of thrombo-inflammatory complications and reduce the mortality rate among COVID-19 patients. In conclusion, an in-depth understanding of platelet–SARS-CoV-2 interactions may uncover novel mechanisms underlying severe COVID-19 complications and could provide new therapeutic avenues for managing this disease.https://www.mdpi.com/1422-0067/24/18/14133plateletthrombosisSARS-CoV-2COVID-19 |
| spellingShingle | Junyi Zhao Xiafan Xu Yifei Gao Yijing Yu Conglei Li Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 International Journal of Molecular Sciences platelet thrombosis SARS-CoV-2 COVID-19 |
| title | Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 |
| title_full | Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 |
| title_fullStr | Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 |
| title_full_unstemmed | Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 |
| title_short | Crosstalk between Platelets and SARS-CoV-2: Implications in Thrombo-Inflammatory Complications in COVID-19 |
| title_sort | crosstalk between platelets and sars cov 2 implications in thrombo inflammatory complications in covid 19 |
| topic | platelet thrombosis SARS-CoV-2 COVID-19 |
| url | https://www.mdpi.com/1422-0067/24/18/14133 |
| work_keys_str_mv | AT junyizhao crosstalkbetweenplateletsandsarscov2implicationsinthromboinflammatorycomplicationsincovid19 AT xiafanxu crosstalkbetweenplateletsandsarscov2implicationsinthromboinflammatorycomplicationsincovid19 AT yifeigao crosstalkbetweenplateletsandsarscov2implicationsinthromboinflammatorycomplicationsincovid19 AT yijingyu crosstalkbetweenplateletsandsarscov2implicationsinthromboinflammatorycomplicationsincovid19 AT congleili crosstalkbetweenplateletsandsarscov2implicationsinthromboinflammatorycomplicationsincovid19 |