State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery
Respiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary disease), ARDS (acute respiratory distress syndrome), and COVID-...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/17/6435 |
| _version_ | 1797554667240030208 |
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| author | Hosanna Brave Ronan MacLoughlin |
| author_facet | Hosanna Brave Ronan MacLoughlin |
| author_sort | Hosanna Brave |
| collection | DOAJ |
| description | Respiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary disease), ARDS (acute respiratory distress syndrome), and COVID-19. Novel and innovative therapies such as advanced therapy medicinal products (ATMPs) are still in early development. However, they have exhibited significant potential preclinically and clinically. There are several longitudinal studies published, primarily focusing on the use of cell therapies for respiratory diseases due to their anti-inflammatory and reparative properties, thereby hinting that they have the capability of reducing mortality and improving the quality of life for patients. The primary objective of this paper is to set out a state of the art review on the use of aerosolized MSCs and their potential to treat these incurable diseases. This review will examine selected respiratory and pulmonary diseases, present an overview of the therapeutic potential of cell therapy and finally provide insight into potential routes of administration, with a focus on aerosol-mediated ATMP delivery. |
| first_indexed | 2024-03-10T16:35:18Z |
| format | Article |
| id | doaj.art-e3b6abe0d5a94aabb09a1366e31155d5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:35:18Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e3b6abe0d5a94aabb09a1366e31155d52023-11-20T12:30:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012117643510.3390/ijms21176435State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol DeliveryHosanna Brave0Ronan MacLoughlin1College of Medicine, Nursing & Health Sciences, National University of Ireland, H91 TK33 Galway, IrelandDepartment of Chemistry, Royal College of Surgeons in Ireland, D02 YN77 Dublin, IrelandRespiratory and pulmonary diseases are among the leading causes of death globally. Despite tremendous advancements, there are no effective pharmacological therapies capable of curing diseases such as COPD (chronic obstructive pulmonary disease), ARDS (acute respiratory distress syndrome), and COVID-19. Novel and innovative therapies such as advanced therapy medicinal products (ATMPs) are still in early development. However, they have exhibited significant potential preclinically and clinically. There are several longitudinal studies published, primarily focusing on the use of cell therapies for respiratory diseases due to their anti-inflammatory and reparative properties, thereby hinting that they have the capability of reducing mortality and improving the quality of life for patients. The primary objective of this paper is to set out a state of the art review on the use of aerosolized MSCs and their potential to treat these incurable diseases. This review will examine selected respiratory and pulmonary diseases, present an overview of the therapeutic potential of cell therapy and finally provide insight into potential routes of administration, with a focus on aerosol-mediated ATMP delivery.https://www.mdpi.com/1422-0067/21/17/6435mesenchymal stem cellconditioned mediaaerosolrespiratoryATMPexosomes |
| spellingShingle | Hosanna Brave Ronan MacLoughlin State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery International Journal of Molecular Sciences mesenchymal stem cell conditioned media aerosol respiratory ATMP exosomes |
| title | State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery |
| title_full | State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery |
| title_fullStr | State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery |
| title_full_unstemmed | State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery |
| title_short | State of the Art Review of Cell Therapy in the Treatment of Lung Disease, and the Potential for Aerosol Delivery |
| title_sort | state of the art review of cell therapy in the treatment of lung disease and the potential for aerosol delivery |
| topic | mesenchymal stem cell conditioned media aerosol respiratory ATMP exosomes |
| url | https://www.mdpi.com/1422-0067/21/17/6435 |
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