A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion
Background: Oxidized low-density lipoprotein (ox-LDL) has been implicated in atherosclerotic cardiovascular disease. Arteriolosclerosis is an important causative factor for retinal vein occlusion (RVO). Till, date there is dearth of literature on ox-LDL and RVO. Aims and Objectives: The objective...
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2023-05-01
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| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/51305 |
| _version_ | 1827956308597276672 |
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| author | Kapil Deb Lahiri Amit Kumar Gupta Utpal Kumar Biswas |
| author_facet | Kapil Deb Lahiri Amit Kumar Gupta Utpal Kumar Biswas |
| author_sort | Kapil Deb Lahiri |
| collection | DOAJ |
| description | Background: Oxidized low-density lipoprotein (ox-LDL) has been implicated in atherosclerotic cardiovascular disease. Arteriolosclerosis is an important causative factor for retinal vein occlusion (RVO). Till, date there is dearth of literature on ox-LDL and RVO.
Aims and Objectives: The objectives of this study were to see whether ox-LDL cholesterol is an independent risk factor in RVO with normal lipid profile.
Materials and Methods: Lipid profiles and ox-LDL levels were assayed in 122 adult unilateral RVO cases and 142 age and sex matched controls in this 1 year old case–control study.
Results: ox-LDL cholesterol levels were significantly elevated in RVO cases than controls (54.5±6.1 in cases vs. 36.6±5.6 in controls, P<0.01), although serum lipid profiles were normal in both cases and controls.
Conclusion: The ox-LDL-induced atherosclerosis may be responsible for the retinal venous occlusion in absence of other risk factors. Hence, screening for ox-LDL in RVO patients should be worth considering especially in patients with normal lipid profiles. |
| first_indexed | 2024-04-09T15:02:22Z |
| format | Article |
| id | doaj.art-e3b7b4f8ac1042969952883d5a36d43b |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-09T15:02:22Z |
| publishDate | 2023-05-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-e3b7b4f8ac1042969952883d5a36d43b2023-05-01T15:19:28ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762023-05-011457174https://doi.org/10.3126/ajms.v14i5.51305A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusionKapil Deb Lahiri 0https://orcid.org/0000-0002-4972-2886Amit Kumar Gupta 1https://orcid.org/0000-0002-5528-1052Utpal Kumar Biswas 2https://orcid.org/0000-0002-4714-0065Associate Professor, Department of Biochemistry, Raiganj Government Medical College, Raiganj, West Bengal, India Associate Professor, Department of Ophthalmology, IPGME and R-SSKM Hospital, Kolkata, West Bengal, India Professor, Department of Biochemistry, North Bengal Medical College, Siliguri, West Bengal, India Background: Oxidized low-density lipoprotein (ox-LDL) has been implicated in atherosclerotic cardiovascular disease. Arteriolosclerosis is an important causative factor for retinal vein occlusion (RVO). Till, date there is dearth of literature on ox-LDL and RVO. Aims and Objectives: The objectives of this study were to see whether ox-LDL cholesterol is an independent risk factor in RVO with normal lipid profile. Materials and Methods: Lipid profiles and ox-LDL levels were assayed in 122 adult unilateral RVO cases and 142 age and sex matched controls in this 1 year old case–control study. Results: ox-LDL cholesterol levels were significantly elevated in RVO cases than controls (54.5±6.1 in cases vs. 36.6±5.6 in controls, P<0.01), although serum lipid profiles were normal in both cases and controls. Conclusion: The ox-LDL-induced atherosclerosis may be responsible for the retinal venous occlusion in absence of other risk factors. Hence, screening for ox-LDL in RVO patients should be worth considering especially in patients with normal lipid profiles.https://www.nepjol.info/index.php/AJMS/article/view/51305https://doi.org/10.3126/ajms.v14i5.51305 |
| spellingShingle | Kapil Deb Lahiri Amit Kumar Gupta Utpal Kumar Biswas A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion Asian Journal of Medical Sciences https://doi.org/10.3126/ajms.v14i5.51305 |
| title | A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion |
| title_full | A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion |
| title_fullStr | A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion |
| title_full_unstemmed | A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion |
| title_short | A study on oxidized-LDL cholesterol in normolipidemic retinal vein occlusion |
| title_sort | study on oxidized ldl cholesterol in normolipidemic retinal vein occlusion |
| topic | https://doi.org/10.3126/ajms.v14i5.51305 |
| url | https://www.nepjol.info/index.php/AJMS/article/view/51305 |
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