Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM
ObjectiveThis study aims to study the correlation between serum β2-glycoprotein I (β2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral infarction in patients with type 2 diabetes (T2DM).MethodsFrom January 2019 to March 2021, 56 patients with T2DM combined with cerebral infarct...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.930701/full |
| _version_ | 1818488719119745024 |
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| author | Wending Kuang Yi Li Gang Liu Yang Zhang Gang Chen Bang Luo Shuangyu Kuang |
| author_facet | Wending Kuang Yi Li Gang Liu Yang Zhang Gang Chen Bang Luo Shuangyu Kuang |
| author_sort | Wending Kuang |
| collection | DOAJ |
| description | ObjectiveThis study aims to study the correlation between serum β2-glycoprotein I (β2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral infarction in patients with type 2 diabetes (T2DM).MethodsFrom January 2019 to March 2021, 56 patients with T2DM combined with cerebral infarction were chosen as a diabetic cerebral infarction (DCI) group, and 60 patients with simple T2DM were chosen as a T2DM group. In addition, 60 healthy volunteers were recruited as a control group. The essential information of each group was collected, and the serum β2-GPI/oxLDL and inflammatory factor levels in each group were compared. The clinical factors that affect the risk of ischemic cerebral infarction in patients with T2DM were analyzed by a logistic model.ResultsCompared with the control group, the level of serum β2-GPI/oxLDL in the T2DM and DCI groups increased significantly, P < 0.001. Compared with the T2DM group, the serum β2-GPI/oxLDL level in the DCI group increased significantly, P < 0.05. The result of Pearson’s correlation analysis showed that serum β2-GPI/oxLDL was positively correlated with total cholesterol, triglycerides, fasting blood glucose, 2-h postprandial blood glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor (TNF)-α (all P’s < 0.05). Serum TNF-α and β2-GPI/oxLDL were independent risk variates for DCI (P < 0.05). Based on the receiver operating characteristic curve analysis, the values of the area under the curve for TNF-α, serum β2-GPI/oxLDL, and the combined diagnosis of DCI were 0.653 (0.552–0.753), 0.680 (0.583–0.777), 0.739 (0.647–0.831), respectively.ConclusionIn DCI patients, the levels of serum oxLDL/β2-GPI are significantly increased. Serum oxLDL/β2-GPI is an independent risk factor that affects the occurrence of DCI. In addition, the serum β2-GPI/oxLDL level implicates the lipid metabolism and inflammatory status of the internal environment of DCI patients to a certain extent. |
| first_indexed | 2024-12-10T16:54:48Z |
| format | Article |
| id | doaj.art-e3b895a134bb43bf957ce12fa4c15529 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-12-10T16:54:48Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-e3b895a134bb43bf957ce12fa4c155292022-12-22T01:40:47ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-07-01910.3389/fsurg.2022.930701930701Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DMWending Kuang0Yi Li1Gang Liu2Yang Zhang3Gang Chen4Bang Luo5Shuangyu Kuang6The Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Diagnosis, Hengyang Medical School, University of South China, Hengyang, ChinaThe Second Affiliated Hospital, Department of Endocrinology, Hengyang Medical School, University of South China, Hengyang, ChinaThe Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, ChinaThe Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, ChinaThe Second Affiliated Hospital, Department of Neurology, Hengyang Medical School, University of South China, Hengyang, ChinaThe Second Affiliated Hospital, Department of GCP, Hengyang Medical School, University of South China, Hengyang, ChinaObjectiveThis study aims to study the correlation between serum β2-glycoprotein I (β2-GPI)/oxidized low-density lipoprotein (oxLDL) and the risk of cerebral infarction in patients with type 2 diabetes (T2DM).MethodsFrom January 2019 to March 2021, 56 patients with T2DM combined with cerebral infarction were chosen as a diabetic cerebral infarction (DCI) group, and 60 patients with simple T2DM were chosen as a T2DM group. In addition, 60 healthy volunteers were recruited as a control group. The essential information of each group was collected, and the serum β2-GPI/oxLDL and inflammatory factor levels in each group were compared. The clinical factors that affect the risk of ischemic cerebral infarction in patients with T2DM were analyzed by a logistic model.ResultsCompared with the control group, the level of serum β2-GPI/oxLDL in the T2DM and DCI groups increased significantly, P < 0.001. Compared with the T2DM group, the serum β2-GPI/oxLDL level in the DCI group increased significantly, P < 0.05. The result of Pearson’s correlation analysis showed that serum β2-GPI/oxLDL was positively correlated with total cholesterol, triglycerides, fasting blood glucose, 2-h postprandial blood glucose, glycosylated hemoglobin, interleukin-6, and tumor necrosis factor (TNF)-α (all P’s < 0.05). Serum TNF-α and β2-GPI/oxLDL were independent risk variates for DCI (P < 0.05). Based on the receiver operating characteristic curve analysis, the values of the area under the curve for TNF-α, serum β2-GPI/oxLDL, and the combined diagnosis of DCI were 0.653 (0.552–0.753), 0.680 (0.583–0.777), 0.739 (0.647–0.831), respectively.ConclusionIn DCI patients, the levels of serum oxLDL/β2-GPI are significantly increased. Serum oxLDL/β2-GPI is an independent risk factor that affects the occurrence of DCI. In addition, the serum β2-GPI/oxLDL level implicates the lipid metabolism and inflammatory status of the internal environment of DCI patients to a certain extent.https://www.frontiersin.org/articles/10.3389/fsurg.2022.930701/fulloxLDLβ2-GPIcerebral infarctiontype 2 diabetesT2DM |
| spellingShingle | Wending Kuang Yi Li Gang Liu Yang Zhang Gang Chen Bang Luo Shuangyu Kuang Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM Frontiers in Surgery oxLDL β2-GPI cerebral infarction type 2 diabetes T2DM |
| title | Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM |
| title_full | Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM |
| title_fullStr | Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM |
| title_full_unstemmed | Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM |
| title_short | Correlation Between Serum β2-GPI/oxLDL and the Risk of Cerebral Infarction in Patients with T2DM |
| title_sort | correlation between serum β2 gpi oxldl and the risk of cerebral infarction in patients with t2dm |
| topic | oxLDL β2-GPI cerebral infarction type 2 diabetes T2DM |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.930701/full |
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