Arsenic causing gallbladder cancer disease in Bihar
Abstract In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis. In the present study, n = 200 were control vol...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-30898-0 |
| _version_ | 1797865155347873792 |
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| author | Arun Kumar Mohammad Ali Vivek Raj Arti Kumari Mahesh Rachamalla Som Niyogi Dhruv Kumar Ashok Sharma Amit Saxena Ghanish Panjawani Preeti Jain Ajay Vidyarthi Navin Kumar Mukesh Kumar Pintoo Kumar Niraj Md. Samiur Rahman Akhouri Bishwapriya Ranjit Kumar Maiko Sakamoto Santosh Kumar Manisha Singh Ashok Kumar Ghosh |
| author_facet | Arun Kumar Mohammad Ali Vivek Raj Arti Kumari Mahesh Rachamalla Som Niyogi Dhruv Kumar Ashok Sharma Amit Saxena Ghanish Panjawani Preeti Jain Ajay Vidyarthi Navin Kumar Mukesh Kumar Pintoo Kumar Niraj Md. Samiur Rahman Akhouri Bishwapriya Ranjit Kumar Maiko Sakamoto Santosh Kumar Manisha Singh Ashok Kumar Ghosh |
| author_sort | Arun Kumar |
| collection | DOAJ |
| description | Abstract In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis. In the present study, n = 200 were control volunteers and n = 152 confirmed gallbladder cancer cases. The studied GBC patient’s biological samples-gallbladder tissue, gallbladder stone, bile, blood and hair samples were collected for arsenic estimation. Moreover, n = 512 gallbladder cancer patients blood samples were also evaluated for the presence of arsenic to understand exposure level in the population. A significantly high arsenic concentration (p < 0.05) was detected in the blood samples with maximum concentration 389 µg/L in GBC cases in comparison to control. Similarly, in the gallbladder cancer patients, there was significantly high arsenic concentration observed in gallbladder tissue with highest concentration of 2166 µg/kg, in gallbladder stones 635 µg/kg, in bile samples 483 µg/L and in hair samples 6980 µg/kg respectively. Moreover, the n = 512 gallbladder cancer patient’s blood samples study revealed very significant arsenic concentration in the population of Bihar with maximum arsenic concentration as 746 µg/L. The raised arsenic concentration in the gallbladder cancer patients’ biological samples—gallbladder tissue, gallbladder stone, bile, blood, and hair samples was significantly very high in the arsenic exposed area. The study denotes that the gallbladder disease burden is very high in the arsenic exposed area of Bihar. The findings do provide a strong link between arsenic contamination and increased gallbladder carcinogenesis. |
| first_indexed | 2024-04-09T23:03:23Z |
| format | Article |
| id | doaj.art-e3bae0f26b08454c9822597fb7063c37 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T23:03:23Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e3bae0f26b08454c9822597fb7063c372023-03-22T10:51:27ZengNature PortfolioScientific Reports2045-23222023-03-0113111610.1038/s41598-023-30898-0Arsenic causing gallbladder cancer disease in BiharArun Kumar0Mohammad Ali1Vivek Raj2Arti Kumari3Mahesh Rachamalla4Som Niyogi5Dhruv Kumar6Ashok Sharma7Amit Saxena8Ghanish Panjawani9Preeti Jain10Ajay Vidyarthi11Navin Kumar12Mukesh Kumar13Pintoo Kumar Niraj14Md. Samiur Rahman15Akhouri Bishwapriya16Ranjit Kumar17Maiko Sakamoto18Santosh Kumar19Manisha Singh20Ashok Kumar Ghosh21Mahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreDepartment of Biotechnology, Patna Women’s CollegeUniversity of SaskatchewanUniversity of SaskatchewanSchool of Health Sciences & Technology, UPES UniversityAll India Institute of Medical SciencesCentre for Development of Advanced Computing (C-DAC)Mahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreGeological Survey of IndiaCentral University of Himachal PradeshUniversity of TokyoDelft University of TechnologyMahavir Cancer Sansthan and Research CentreMahavir Cancer Sansthan and Research CentreAbstract In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are being reported from arsenic hotspots identified in Bihar. The study aims to establish association between arsenic exposure and gallbladder carcinogenesis. In the present study, n = 200 were control volunteers and n = 152 confirmed gallbladder cancer cases. The studied GBC patient’s biological samples-gallbladder tissue, gallbladder stone, bile, blood and hair samples were collected for arsenic estimation. Moreover, n = 512 gallbladder cancer patients blood samples were also evaluated for the presence of arsenic to understand exposure level in the population. A significantly high arsenic concentration (p < 0.05) was detected in the blood samples with maximum concentration 389 µg/L in GBC cases in comparison to control. Similarly, in the gallbladder cancer patients, there was significantly high arsenic concentration observed in gallbladder tissue with highest concentration of 2166 µg/kg, in gallbladder stones 635 µg/kg, in bile samples 483 µg/L and in hair samples 6980 µg/kg respectively. Moreover, the n = 512 gallbladder cancer patient’s blood samples study revealed very significant arsenic concentration in the population of Bihar with maximum arsenic concentration as 746 µg/L. The raised arsenic concentration in the gallbladder cancer patients’ biological samples—gallbladder tissue, gallbladder stone, bile, blood, and hair samples was significantly very high in the arsenic exposed area. The study denotes that the gallbladder disease burden is very high in the arsenic exposed area of Bihar. The findings do provide a strong link between arsenic contamination and increased gallbladder carcinogenesis.https://doi.org/10.1038/s41598-023-30898-0 |
| spellingShingle | Arun Kumar Mohammad Ali Vivek Raj Arti Kumari Mahesh Rachamalla Som Niyogi Dhruv Kumar Ashok Sharma Amit Saxena Ghanish Panjawani Preeti Jain Ajay Vidyarthi Navin Kumar Mukesh Kumar Pintoo Kumar Niraj Md. Samiur Rahman Akhouri Bishwapriya Ranjit Kumar Maiko Sakamoto Santosh Kumar Manisha Singh Ashok Kumar Ghosh Arsenic causing gallbladder cancer disease in Bihar Scientific Reports |
| title | Arsenic causing gallbladder cancer disease in Bihar |
| title_full | Arsenic causing gallbladder cancer disease in Bihar |
| title_fullStr | Arsenic causing gallbladder cancer disease in Bihar |
| title_full_unstemmed | Arsenic causing gallbladder cancer disease in Bihar |
| title_short | Arsenic causing gallbladder cancer disease in Bihar |
| title_sort | arsenic causing gallbladder cancer disease in bihar |
| url | https://doi.org/10.1038/s41598-023-30898-0 |
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