Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7
AbstractBackground: Transcription factor 4 (TCF4) is found to be associated with schizophrenia. TCF4 mutations also cause Pitt-Hopkins Syndrome, a neurodevelopmental disorder associated with severe mental retardation. However, the function of TCF4 during brain development remains unclear. Results: H...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-10-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00094/full |
| _version_ | 1818681584585277440 |
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| author | Tianda Chen qinwei wu yang zhang tianlan lu weihua yue dai zhang |
| author_facet | Tianda Chen qinwei wu yang zhang tianlan lu weihua yue dai zhang |
| author_sort | Tianda Chen |
| collection | DOAJ |
| description | AbstractBackground: Transcription factor 4 (TCF4) is found to be associated with schizophrenia. TCF4 mutations also cause Pitt-Hopkins Syndrome, a neurodevelopmental disorder associated with severe mental retardation. However, the function of TCF4 during brain development remains unclear. Results: Here, we report that Tcf4 is expressed in the developing cerebral cortex. In utero suppression of Tcf4 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. Knockdown of Tcf4 impaired leading process formation. Furthermore, Bone Morphogenetic Protein 7 (Bmp7) is upregulated in Tcf4-deficient neurons. In vivo gain of function and rescue experiments demonstrated that Bmp7 is the major downstream effector of Tcf4 required for neuronal migration. Conclusion: Thus, we have uncovered a new Tcf4/Bmp7-dependent mechanism underlying neuronal migration, and provide insights into the pathogenesis of neurodevelopmental disorders. |
| first_indexed | 2024-12-17T10:05:16Z |
| format | Article |
| id | doaj.art-e3bb0e8dfa7d4261a36383fe73b97c8d |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-17T10:05:16Z |
| publishDate | 2016-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-e3bb0e8dfa7d4261a36383fe73b97c8d2022-12-21T21:53:12ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992016-10-01910.3389/fnmol.2016.00094210984Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7Tianda Chen0qinwei wu1yang zhang2tianlan lu3weihua yue4dai zhang5Peking universityPeking universityPeking universityPeking universityPeking universityPeking universityAbstractBackground: Transcription factor 4 (TCF4) is found to be associated with schizophrenia. TCF4 mutations also cause Pitt-Hopkins Syndrome, a neurodevelopmental disorder associated with severe mental retardation. However, the function of TCF4 during brain development remains unclear. Results: Here, we report that Tcf4 is expressed in the developing cerebral cortex. In utero suppression of Tcf4 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. Knockdown of Tcf4 impaired leading process formation. Furthermore, Bone Morphogenetic Protein 7 (Bmp7) is upregulated in Tcf4-deficient neurons. In vivo gain of function and rescue experiments demonstrated that Bmp7 is the major downstream effector of Tcf4 required for neuronal migration. Conclusion: Thus, we have uncovered a new Tcf4/Bmp7-dependent mechanism underlying neuronal migration, and provide insights into the pathogenesis of neurodevelopmental disorders.http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00094/fullSchizophrenianeuronal migrationBrain DevelopmentBmp7TCF4 |
| spellingShingle | Tianda Chen qinwei wu yang zhang tianlan lu weihua yue dai zhang Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 Frontiers in Molecular Neuroscience Schizophrenia neuronal migration Brain Development Bmp7 TCF4 |
| title | Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 |
| title_full | Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 |
| title_fullStr | Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 |
| title_full_unstemmed | Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 |
| title_short | Tcf4 controls neuronal migration of the cerebral cortex through regulation of Bmp7 |
| title_sort | tcf4 controls neuronal migration of the cerebral cortex through regulation of bmp7 |
| topic | Schizophrenia neuronal migration Brain Development Bmp7 TCF4 |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00094/full |
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