ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

ICOS DNA methylation regulates melanoma cell-intrinsic ICOS expression, is associated with melanoma differentiation, prognosis, and predicts response to immune checkpoint blockade

Abstract Background Inducible T cell costimulator ICOS is an emerging target in immuno-oncology. The aim of this study was to investigate the epigenetic regulation of ICOS in melanoma by DNA methylation. Methods We comprehensively investigate ICOS DNA methylation of specific CpG sites and expression...

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Bibliographic Details
Main Authors: Damian J. Ralser, Emmanuelle Herr, Luka de Vos, Zsófi Kulcsár, Romina Zarbl, Niklas Klümper, Gerrit H. Gielen, Alexander Philippe Maas, Friederike Hoffmann, Jörn Dietrich, Pia Kuster, Alexander Mustea, Nicole Glodde, Glen Kristiansen, Sebastian Strieth, Jennifer Landsberg, Dimo Dietrich
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Biomarker Research
Subjects:
ICOS
ICOS DNA methylation
Epigenetics
Immune checkpoint blockade
Melanoma
Predictive biomarker
Online Access:https://doi.org/10.1186/s40364-023-00508-2

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