SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids

SARS-CoV-2 omicron BA.5 and XBB variants have increased neurotropic potential over BA.1 in K18-hACE2 mice and human brain organoids

The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 and XBB remains controversial. We show that BA.5 and XBB isolates were significantly more pathogenic in K18-hACE2 mice...

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Bibliographic Details
Main Authors: Romal Stewart, Kexin Yan, Sevannah A. Ellis, Cameron R. Bishop, Troy Dumenil, Bing Tang, Wilson Nguyen, Thibaut Larcher, Rhys Parry, Julian De Jun Sng, Alexander A. Khromykh, Robert K. P. Sullivan, Mary Lor, Frédéric A. Meunier, Daniel J. Rawle, Andreas Suhrbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Microbiology
Subjects:
SARS-CoV-2
omicron
XBB
BA.5
K18-hACE2
brain
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1320856/full

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