Association between ACYP2 polymorphisms and the risk of renal cell cancer
Abstract Background Kidney cancer is the predominant form of malignancy of the kidney and accounts for approximately 3%–4% of all cancers. Renal cell cancer (RCC) represents more than 85% of kidney cancer. It has been reported that genetic factors may predispose individuals to RCC. This study evalua...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-11-01
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| Series: | Molecular Genetics & Genomic Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mgg3.966 |
| _version_ | 1797296172055920640 |
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| author | Yuhe Wang Yongtong Zhang Yao Sun Jiamin Wu Junke Chang Zichao Xiong Fanglin Niu Shanzhi Gu Tianbo Jin |
| author_facet | Yuhe Wang Yongtong Zhang Yao Sun Jiamin Wu Junke Chang Zichao Xiong Fanglin Niu Shanzhi Gu Tianbo Jin |
| author_sort | Yuhe Wang |
| collection | DOAJ |
| description | Abstract Background Kidney cancer is the predominant form of malignancy of the kidney and accounts for approximately 3%–4% of all cancers. Renal cell cancer (RCC) represents more than 85% of kidney cancer. It has been reported that genetic factors may predispose individuals to RCC. This study evaluated the association between Acylphosphatase 2 (ACYP2) gene polymorphisms and RCC risk in the Han Chinese population. Methods Twelve single‐nucleotide polymorphisms (SNPs) in ACYP2 were genotyped using the Agena MassARRAY platform from 293 RCC patients and 495 controls. The Chi‐squared test, genetic models, haplotype, and stratification analyses were used to evaluate the association between SNPs and the risk of RCC. The relative risk was estimated using the odds ratio (OR) and 95% confidence interval (CI). Results We observed that the rs6713088 allele G (OR = 1.26, 95% CI: 1.03–1.53, p = .023) and rs843711 allele T (OR = 1.29, 95% CI: 1.06–1.57, p = .010) were associated with increased RCC risk. Genetic model analyses found that rs843711 was significantly associated with an increased RCC risk under the recessive model and log‐additive model after adjusting for age and gender. Haplotype analysis showed that the haplotype “TTCTCGCC” (OR = 0.67, 95% CI: 0.48–0.94, p = .021) was associated with a decreased risk of RCC in the Han Chinese population. Stratification analysis also found that rs6713088 and rs843711 were significantly associated with increased RCC risk. Conclusion In summary, the results suggested that ACYP2 polymorphisms could be used as a genetic marker for RCC. Additional functional and association studies are required to validate our results. |
| first_indexed | 2024-03-07T21:58:36Z |
| format | Article |
| id | doaj.art-e3bc0793a1e14730b82f15f925aab054 |
| institution | Directory Open Access Journal |
| issn | 2324-9269 |
| language | English |
| last_indexed | 2024-03-07T21:58:36Z |
| publishDate | 2019-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Molecular Genetics & Genomic Medicine |
| spelling | doaj.art-e3bc0793a1e14730b82f15f925aab0542024-02-24T07:01:11ZengWileyMolecular Genetics & Genomic Medicine2324-92692019-11-01711n/an/a10.1002/mgg3.966Association between ACYP2 polymorphisms and the risk of renal cell cancerYuhe Wang0Yongtong Zhang1Yao Sun2Jiamin Wu3Junke Chang4Zichao Xiong5Fanglin Niu6Shanzhi Gu7Tianbo Jin8Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang Shaanxi ChinaDepartment of Radiotherapy Shaanxi Provincial Cancer Hospital Xi’an Shaanxi ChinaKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education School of Life Sciences Northwest University Xi’an Shaanxi ChinaKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education School of Life Sciences Northwest University Xi’an Shaanxi ChinaXi’an Jiaotong University Health Science Center Xi’an Shaanxi ChinaKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education School of Life Sciences Northwest University Xi’an Shaanxi ChinaKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University) Ministry of Education School of Life Sciences Northwest University Xi’an Shaanxi ChinaThe Key Laboratory of Health Ministry for Forensic Science Xi'an Jiaotong University Xi’an Shaanxi ChinaKey Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region School of Medicine Xizang Minzu University Xianyang Shaanxi ChinaAbstract Background Kidney cancer is the predominant form of malignancy of the kidney and accounts for approximately 3%–4% of all cancers. Renal cell cancer (RCC) represents more than 85% of kidney cancer. It has been reported that genetic factors may predispose individuals to RCC. This study evaluated the association between Acylphosphatase 2 (ACYP2) gene polymorphisms and RCC risk in the Han Chinese population. Methods Twelve single‐nucleotide polymorphisms (SNPs) in ACYP2 were genotyped using the Agena MassARRAY platform from 293 RCC patients and 495 controls. The Chi‐squared test, genetic models, haplotype, and stratification analyses were used to evaluate the association between SNPs and the risk of RCC. The relative risk was estimated using the odds ratio (OR) and 95% confidence interval (CI). Results We observed that the rs6713088 allele G (OR = 1.26, 95% CI: 1.03–1.53, p = .023) and rs843711 allele T (OR = 1.29, 95% CI: 1.06–1.57, p = .010) were associated with increased RCC risk. Genetic model analyses found that rs843711 was significantly associated with an increased RCC risk under the recessive model and log‐additive model after adjusting for age and gender. Haplotype analysis showed that the haplotype “TTCTCGCC” (OR = 0.67, 95% CI: 0.48–0.94, p = .021) was associated with a decreased risk of RCC in the Han Chinese population. Stratification analysis also found that rs6713088 and rs843711 were significantly associated with increased RCC risk. Conclusion In summary, the results suggested that ACYP2 polymorphisms could be used as a genetic marker for RCC. Additional functional and association studies are required to validate our results.https://doi.org/10.1002/mgg3.966ACYP2case‐controlChinese Hanpolymorphismrenal cell cancer |
| spellingShingle | Yuhe Wang Yongtong Zhang Yao Sun Jiamin Wu Junke Chang Zichao Xiong Fanglin Niu Shanzhi Gu Tianbo Jin Association between ACYP2 polymorphisms and the risk of renal cell cancer Molecular Genetics & Genomic Medicine ACYP2 case‐control Chinese Han polymorphism renal cell cancer |
| title | Association between ACYP2 polymorphisms and the risk of renal cell cancer |
| title_full | Association between ACYP2 polymorphisms and the risk of renal cell cancer |
| title_fullStr | Association between ACYP2 polymorphisms and the risk of renal cell cancer |
| title_full_unstemmed | Association between ACYP2 polymorphisms and the risk of renal cell cancer |
| title_short | Association between ACYP2 polymorphisms and the risk of renal cell cancer |
| title_sort | association between acyp2 polymorphisms and the risk of renal cell cancer |
| topic | ACYP2 case‐control Chinese Han polymorphism renal cell cancer |
| url | https://doi.org/10.1002/mgg3.966 |
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